Advances in Continuous Flow Calorimetry

Timothy Aljoscha Frede, Manuel C. Maier, Norbert Kockmann*, Heidrun Gruber-Woelfler

*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)Begutachtung


Calorimetric data from chemical reactions such as reaction enthalpy, adiabatic temperature rise, and activation energy are essential for reaction safety and scale-up from laboratory investigations to reactor design and operation. Typically, these data are gained from batch calorimeters with sophisticated setups and elaborate measurement procedures. Continuous flow calorimeters, compared with batch setups, have different mixing and heat transfer characteristics and enable harsh reaction conditions, particularly within microstructured reactors with their enhanced heat transfer capability. This review provides an overview of currently investigated and applied flow calorimeters in research and development in relation to existing concepts. Novel approaches for heat flux measurements as well as integrated sensors are presented. Safety aspects of flow chemistry are a main driver, but additionally, low material consumption is important in early process development. Limitations of the concepts are presented with a comprehensive literature overview of flow calorimetry to show that continuous flow calorimeters form a new tool in process development and safety engineering, particularly with microstructured devices and novel sensing techniques.

Seiten (von - bis)267-277
FachzeitschriftOrganic Process Research and Development
PublikationsstatusVeröffentlicht - 18 Feb. 2022

ASJC Scopus subject areas

  • Physikalische und Theoretische Chemie
  • Organische Chemie


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