Challenges in the Simulation of Drying in Fluid Bed Granulation

Maryam Askarishahi*, Mohammadsadegh Salehi, Stefan Radl

*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)Begutachtung

Abstract

Fluid bed granulation is faced with a high level of complexity due to the simultaneous occurrence of agglomeration, breakage, and drying. These complexities should be thoroughly investigated through particle–particle, particle–droplet, and particle–fluid interactions to understand the process better. The present contribution focuses on the importance of drying and the associated challenges when modeling a granulation process. To do so, initially, we will present a summary of the numerical approaches, from micro-scale to macro-scale, used for the simulation of drying and agglomeration in fluid bed granulators. Depending on the modeled scale, each approach features several advantages and challenges. We classified the imposed challenges based on their contributions to the drying rate. Then, we critically scrutinized how these challenges have been addressed in the literature. Our review identifies some of the main challenges related to (i) the interaction of droplets with particles; (ii) the drying kinetics of granules and its dependence on agglomeration/breakage processes; as well as (iii) the determination of drying rates. Concerning the latter, specifically the surface area available for drying needs to be differentiated based on the state of the liquid in the granule: we propose to do this in the form of surface liquid, pore liquid, and the liquid bridging the primary particles.
Originalspracheenglisch
Aufsatznummer569
FachzeitschriftProcesses
Jahrgang11
Ausgabenummer2
DOIs
PublikationsstatusVeröffentlicht - Feb. 2023

ASJC Scopus subject areas

  • Chemische Verfahrenstechnik (sonstige)
  • Bioengineering
  • Prozesschemie und -technologie

Fingerprint

Untersuchen Sie die Forschungsthemen von „Challenges in the Simulation of Drying in Fluid Bed Granulation“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren