TY - JOUR
T1 - Characterization of a Novel Drying Technology for Continuous Processing of Cohesive Materials
T2 - An Ibuprofen Case Study
AU - Zettl, Manuel
AU - Aigner, Isabella
AU - Mannschott, Thomas
AU - Van Der Wel, Peter
AU - Schröttner, Hartmuth
AU - Khinast, Johannes
AU - Krumme, Markus
N1 - Funding Information:
This work has been funded within the Austrian COMET Program under the auspices of the Austrian Federal Ministry of Transport Innovation and Technology (BMVIT), the Austrian Federal Ministry of Economy Family and Youth (BMWFJ), and by the State of Styria (Styrian Funding Agency SFG). COMET is managed by the Austrian Research Promotion Agency FFG. The authors acknowledge the support of Sarah Koller, Jelena Milinkovic Daniel Wiegele, and Patrick Vorraber (All RCPE).
Funding Information:
This work has been funded within the Austrian COMET Program under the auspices of the Austrian Federal Ministry of Transport Innovation, and Technology (BMVIT), the Austrian Federal Ministry of Economy, Family and Youth (BMWFJ), and by the State of Styria (Styrian Funding Agency SFG). COMET is managed by the Austrian Research Promotion Agency FFG. The authors acknowledge the support of Sarah Koller, Jelena Milinkovic, Daniel Wiegele, and Patrick Vorraber (All RCPE).
Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/4/16
Y1 - 2021/4/16
N2 - This work addresses the influence of several process parameters on the performance of a novel drying device (patent NL2020740B1). In the new dryer, the processed substance is conveyed through the grooves of a large rotor via an interlocking screw design. A gentle, forced flow is created, preventing agglomeration and attrition and enabling a new technology of continuous drying for poorly flowing substances, which are often applied in the pharmaceutical industry. Drying test runs are performed using water-wetted ibuprofen, a nonsteroidal anti-inflammatory drug with poor material flow properties. The substances were tested according to their size, shape, and flow properties prior to the test runs. The process parameters in question were the temperature, mass flow, air flow, rotational speed, and initial moisture. Additionally, test runs to estimate the drying mechanism and the long-term process behavior, as well as reprocessing tests of the substance ibuprofen, were executed. It was shown that the dryer's performance for cohesive materials was optimal (continuous process times of up to 10 h were possible with evaporation rates up to 688 g/h). The process was robust, with a few drawbacks related to materials that are prone to tribocharging.
AB - This work addresses the influence of several process parameters on the performance of a novel drying device (patent NL2020740B1). In the new dryer, the processed substance is conveyed through the grooves of a large rotor via an interlocking screw design. A gentle, forced flow is created, preventing agglomeration and attrition and enabling a new technology of continuous drying for poorly flowing substances, which are often applied in the pharmaceutical industry. Drying test runs are performed using water-wetted ibuprofen, a nonsteroidal anti-inflammatory drug with poor material flow properties. The substances were tested according to their size, shape, and flow properties prior to the test runs. The process parameters in question were the temperature, mass flow, air flow, rotational speed, and initial moisture. Additionally, test runs to estimate the drying mechanism and the long-term process behavior, as well as reprocessing tests of the substance ibuprofen, were executed. It was shown that the dryer's performance for cohesive materials was optimal (continuous process times of up to 10 h were possible with evaporation rates up to 688 g/h). The process was robust, with a few drawbacks related to materials that are prone to tribocharging.
KW - agglomeration
KW - cohesive materials
KW - continuous manufacturing
KW - drying
KW - equipment development
KW - temperature sensitive
UR - http://www.scopus.com/inward/record.url?scp=85103388373&partnerID=8YFLogxK
U2 - 10.1021/acs.oprd.0c00413
DO - 10.1021/acs.oprd.0c00413
M3 - Article
AN - SCOPUS:85103388373
SN - 1083-6160
VL - 25
SP - 769
EP - 780
JO - Organic Process Research and Development
JF - Organic Process Research and Development
IS - 4
ER -