Creation of a lipase highly selective for trans fatty acids by protein engineering

Henrike B Brundiek; Andrew S Evitt; Robert Kourist; Uwe T Bornscheuer

doi:10.1002/anie.201106126

Creation of a lipase highly selective for trans fatty acids by protein engineering

Henrike B Brundiek, Andrew S Evitt, Robert Kourist, Uwe T Bornscheuer

Institut für Molekulare Biotechnologie (6550)

Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung

Abstract

Sorting out: Protein engineering of lipase CAL-A led to the discovery of mutants with excellent chemoselectivity for the removal of trans and saturated fatty acids from partially hydrogenated vegetable oil. These fatty acids, identified as a major risk factor for human health, can now be removed by enzyme catalysis.

Originalsprache	englisch
Seiten (von - bis)	412-4
Seitenumfang	3
Fachzeitschrift	Angewandte Chemie - International Edition
Jahrgang	51
Ausgabenummer	2
DOIs	https://doi.org/10.1002/anie.201106126
Publikationsstatus	Veröffentlicht - 9 Jan. 2012

Fields of Expertise

Human- & Biotechnology

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

Zugriff auf Dokument

10.1002/anie.201106126

Dieses zitieren

@article{4a712ac1ac814a338c3ba08f69f966b8,

title = "Creation of a lipase highly selective for trans fatty acids by protein engineering",

abstract = "Sorting out: Protein engineering of lipase CAL-A led to the discovery of mutants with excellent chemoselectivity for the removal of trans and saturated fatty acids from partially hydrogenated vegetable oil. These fatty acids, identified as a major risk factor for human health, can now be removed by enzyme catalysis.",

keywords = "Candida, Hydrogenation, Lipase, Models, Molecular, Mutation, Protein Engineering, Trans Fatty Acids, Journal Article",

author = "Brundiek, {Henrike B} and Evitt, {Andrew S} and Robert Kourist and Bornscheuer, {Uwe T}",

note = "Copyright {\textcopyright} 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2012",

month = jan,

day = "9",

doi = "10.1002/anie.201106126",

language = "English",

volume = "51",

pages = "412--4",

journal = "Angewandte Chemie - International Edition ",

issn = "1433-7851",

publisher = "Wiley-VCH ",

number = "2",

}

TY - JOUR

T1 - Creation of a lipase highly selective for trans fatty acids by protein engineering

AU - Brundiek, Henrike B

AU - Evitt, Andrew S

AU - Kourist, Robert

AU - Bornscheuer, Uwe T

PY - 2012/1/9

Y1 - 2012/1/9

N2 - Sorting out: Protein engineering of lipase CAL-A led to the discovery of mutants with excellent chemoselectivity for the removal of trans and saturated fatty acids from partially hydrogenated vegetable oil. These fatty acids, identified as a major risk factor for human health, can now be removed by enzyme catalysis.

AB - Sorting out: Protein engineering of lipase CAL-A led to the discovery of mutants with excellent chemoselectivity for the removal of trans and saturated fatty acids from partially hydrogenated vegetable oil. These fatty acids, identified as a major risk factor for human health, can now be removed by enzyme catalysis.

KW - Candida

KW - Hydrogenation

KW - Lipase

KW - Models, Molecular

KW - Mutation

KW - Protein Engineering

KW - Trans Fatty Acids

KW - Journal Article

U2 - 10.1002/anie.201106126

DO - 10.1002/anie.201106126

M3 - Article

C2 - 22113941

SN - 1433-7851

VL - 51

SP - 412

EP - 414

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 2

ER -

Creation of a lipase highly selective for trans fatty acids by protein engineering

Abstract

Fields of Expertise

UN SDGs

Zugriff auf Dokument

Fingerprint

Dieses zitieren