Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials

Matias Acosta; Rainer Detsch; Alina Grünewald; Virginia Rojas; Jan Schultheiß; Aleksandra Wajda; Robert W. Stark; Suman Narayan; Maciej Sitarz; Jurij Koruza; Aldo R. Boccaccini

doi:10.1111/jace.15193

Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials

Matias Acosta, Rainer Detsch, Alina Grünewald, Virginia Rojas, Jan Schultheiß, Aleksandra Wajda, Robert W. Stark, Suman Narayan, Maciej Sitarz, Jurij Koruza^*, Aldo R. Boccaccini

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Werkstoffkunde, Fügetechnik und Umformtechnik (3030)

Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung

Abstract

Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1−x) (Na_1/2Bi_1/2)TiO₃–xBaTiO₃, (1−x)Ba(Zr_0.2Ti_0.8)O₃−x(Ba_0.7Ca_0.3)TiO₃, and Pb(Zr,Ti)O₃ to test their suitability as biomaterials. The lead-free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na_1/2Bi_1/2)TiO₃–0.06 mol% BaTiO₃ showed the greatest potential leading to a cell viability of (149 ± 30)% and DNA synthesis of (299 ± 85)% in comparison to the reference. Lead leaching from Pb(Zr,Ti)O₃ negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics.

Originalsprache	englisch
Seiten (von - bis)	440-449
Seitenumfang	10
Fachzeitschrift	Journal of the American Ceramic Society
Jahrgang	101
Ausgabenummer	1
DOIs	https://doi.org/10.1111/jace.15193
Publikationsstatus	Veröffentlicht - Jan. 2018

ASJC Scopus subject areas

Keramische und Verbundwerkstoffe
Werkstoffchemie

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10.1111/jace.15193

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title = "Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials",

abstract = "Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1−x) (Na1/2Bi1/2)TiO3–xBaTiO3, (1−x)Ba(Zr0.2Ti0.8)O3−x(Ba0.7Ca0.3)TiO3, and Pb(Zr,Ti)O3 to test their suitability as biomaterials. The lead-free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na1/2Bi1/2)TiO3–0.06 mol% BaTiO3 showed the greatest potential leading to a cell viability of (149 ± 30)% and DNA synthesis of (299 ± 85)% in comparison to the reference. Lead leaching from Pb(Zr,Ti)O3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics.",

keywords = "biocompatible materials, cytotoxicity, ferroelectrics, mouse embryonic fibroblasts, piezoelectric materials",

author = "Matias Acosta and Rainer Detsch and Alina Gr{\"u}newald and Virginia Rojas and Jan Schulthei{\ss} and Aleksandra Wajda and Stark, {Robert W.} and Suman Narayan and Maciej Sitarz and Jurij Koruza and Boccaccini, {Aldo R.}",

note = "Funding Information: MA acknowledges the support of the Leibniz program under RO954/22-1. JK and JS acknowledge the support of the Deutsche Forschungsgemeinschaft (DFG), Grant Nr. KO 5100/1-1. AW and MS acknowledge the support of the National Science Centre Poland under project 2014/15/B/ ST8/02827. Publisher Copyright: {\textcopyright} 2017 The American Ceramic Society",

year = "2018",

month = jan,

doi = "10.1111/jace.15193",

language = "English",

volume = "101",

pages = "440--449",

journal = "Journal of the American Ceramic Society",

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T1 - Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials

AU - Acosta, Matias

AU - Detsch, Rainer

AU - Grünewald, Alina

AU - Rojas, Virginia

AU - Schultheiß, Jan

AU - Wajda, Aleksandra

AU - Stark, Robert W.

AU - Narayan, Suman

AU - Sitarz, Maciej

AU - Koruza, Jurij

AU - Boccaccini, Aldo R.

N1 - Funding Information: MA acknowledges the support of the Leibniz program under RO954/22-1. JK and JS acknowledge the support of the Deutsche Forschungsgemeinschaft (DFG), Grant Nr. KO 5100/1-1. AW and MS acknowledge the support of the National Science Centre Poland under project 2014/15/B/ ST8/02827. Publisher Copyright: © 2017 The American Ceramic Society

PY - 2018/1

Y1 - 2018/1

N2 - Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1−x) (Na1/2Bi1/2)TiO3–xBaTiO3, (1−x)Ba(Zr0.2Ti0.8)O3−x(Ba0.7Ca0.3)TiO3, and Pb(Zr,Ti)O3 to test their suitability as biomaterials. The lead-free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na1/2Bi1/2)TiO3–0.06 mol% BaTiO3 showed the greatest potential leading to a cell viability of (149 ± 30)% and DNA synthesis of (299 ± 85)% in comparison to the reference. Lead leaching from Pb(Zr,Ti)O3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics.

AB - Surface chemistry and topo-physical properties determine the interactions of biomaterials with their physiological environment. Ferroelectrics hold great promise as the next generation of scaffolds for tissue repair since they feature tunable surface electrical charges, piezoelectricity, and sensing capabilities. We investigate the topography, wettability, chemical stability, and cytotoxicity in salient ferroelectric systems such as (1−x) (Na1/2Bi1/2)TiO3–xBaTiO3, (1−x)Ba(Zr0.2Ti0.8)O3−x(Ba0.7Ca0.3)TiO3, and Pb(Zr,Ti)O3 to test their suitability as biomaterials. The lead-free ferroelectrics promote in vitro cell viability and proliferation to a considerably high extent. 0.94 mol % (Na1/2Bi1/2)TiO3–0.06 mol% BaTiO3 showed the greatest potential leading to a cell viability of (149 ± 30)% and DNA synthesis of (299 ± 85)% in comparison to the reference. Lead leaching from Pb(Zr,Ti)O3 negatively affected the cultured cells. Wettability and chemical stability are key factors that determine the cytotoxicity of ferroelectrics. These variables have to be considered in the design of novel electroactive scaffolds based on ferroelectric ceramics.

KW - biocompatible materials

KW - cytotoxicity

KW - ferroelectrics

KW - mouse embryonic fibroblasts

KW - piezoelectric materials

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U2 - 10.1111/jace.15193

DO - 10.1111/jace.15193

M3 - Article

AN - SCOPUS:85029212950

SN - 0002-7820

VL - 101

SP - 440

EP - 449

JO - Journal of the American Ceramic Society

JF - Journal of the American Ceramic Society

IS - 1

ER -

Cytotoxicity, chemical stability, and surface properties of ferroelectric ceramics for biomaterials

Abstract

ASJC Scopus subject areas

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