TY - JOUR
T1 - Degradation of ZIF-8 in phosphate buffered saline media
AU - Velásquez-Hernández, Miriam De J.
AU - Ricco, Raffaele
AU - Carraro, Francesco
AU - Limpoco, F. Ted
AU - Linares-Moreau, Mercedes
AU - Leitner, Erich
AU - Wiltsche, Helmar
AU - Rattenberger, Johannes
AU - Schröttner, Hartmuth
AU - Frühwirt, Philipp
AU - Stadler, Eduard M.
AU - Gescheidt, Georg
AU - Amenitsch, Heinz
AU - Doonan, Christian J.
AU - Falcaro, Paolo
PY - 2019
Y1 - 2019
N2 - Understanding the stability of zeolitic imidazolate framework-8 (ZIF-8) under physiological conditions is critical in biotechnology and biomedicine for biosensing, biocatalysis, and drug delivery. The use of ZIF-8 has shown that this metal organic framework (MOF) and its derived bio-composites can degrade in presence of buffer solutions. Here we present an in-depth analysis of the structural and chemical changes of pure ZIF-8 particles exposed to phosphate buffered saline (PBS) media. Two different particle sizes (2 μm and 250 nm) were selected and the decomposition operated by 10 mM PBS (aka 1X) was studied using powder X-ray diffraction (PXRD), Fourier transformed infrared spectroscopy (FTIR), time resolved atomic force microscopy (AFM), in situ small angle X-ray scattering (SAXS), and 31P NMR.
AB - Understanding the stability of zeolitic imidazolate framework-8 (ZIF-8) under physiological conditions is critical in biotechnology and biomedicine for biosensing, biocatalysis, and drug delivery. The use of ZIF-8 has shown that this metal organic framework (MOF) and its derived bio-composites can degrade in presence of buffer solutions. Here we present an in-depth analysis of the structural and chemical changes of pure ZIF-8 particles exposed to phosphate buffered saline (PBS) media. Two different particle sizes (2 μm and 250 nm) were selected and the decomposition operated by 10 mM PBS (aka 1X) was studied using powder X-ray diffraction (PXRD), Fourier transformed infrared spectroscopy (FTIR), time resolved atomic force microscopy (AFM), in situ small angle X-ray scattering (SAXS), and 31P NMR.
UR - http://www.scopus.com/inward/record.url?scp=85070316319&partnerID=8YFLogxK
U2 - 10.1039/c9ce00757a
DO - 10.1039/c9ce00757a
M3 - Article
AN - SCOPUS:85070316319
SN - 1466-8033
VL - 21
SP - 4538
EP - 4544
JO - CrystEngComm
JF - CrystEngComm
IS - 31
M1 - 21 (31)
ER -