Abstract
A panel of human flavin monooxygenases were heterologously expressed in E. coli to obtain ready-to-use biocatalysts for the in vitro preparation of human drug metabolites. Moclobemide-N-oxide (65 mg) was the first high-priced metabolite prepared with recombinant hFMO3 on the multi-milligram scale.
Originalsprache | englisch |
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Seiten (von - bis) | 6001-6003 |
Seitenumfang | 3 |
Fachzeitschrift | Chemical Communications |
Jahrgang | 48 |
DOIs | |
Publikationsstatus | Veröffentlicht - 2012 |
Fields of Expertise
- Human- & Biotechnology
Treatment code (Nähere Zuordnung)
- Experimental
- Application