Free-Breathing Liver Fat, R₂* and B₀ Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-Based Reconstruction

Zhengguo Tan, Christina Unterberg-Buchwald, Moritz Blumenthal, Nick Scholand, Philip Schaten, Christian Holme, Xiaoqing Wang, Dirk Raddatz, Martin Uecker

Publikation: Beitrag in einer FachzeitschriftArtikelBegutachtung

Abstract

This work introduced a stack-of-radial multi-echo asymmetric-echo MRI sequence for free-breathing liver volumetric acquisition. Regularized model-based reconstruction was implemented in Berkeley Advanced Reconstruction Toolbox (BART) to jointly estimate all physical parameter maps (water, fat, R2∗ , and B0 field inhomogeneity maps) and coil sensitivity maps from self-gated κ-space data. Specifically, locally low rank and temporal total variation regularization were employed directly on physical parameter maps. The proposed free-breathing radial technique was tested on a water/fat & iron phantom, a young volunteer, and obesity/diabetes/hepatic steatosis patients. Quantitative fat fraction and R2∗ accuracy were confirmed by comparing our technique with the reference breath-hold Cartesian scan. The multi-echo radial sampling sequence achieves fast κ-space coverage and is robust to motion. Moreover, the proposed motion-resolved model-based reconstruction allows for free-breathing liver fat and R2∗ quantification in multiple motion states. Overall, our proposed technique offers a convenient tool for non-invasive liver assessment with no breath holding requirement.

Originalspracheenglisch
Seiten (von - bis)1374-1387
Seitenumfang14
FachzeitschriftIEEE Transactions on Medical Imaging
Jahrgang42
Ausgabenummer5
Frühes Online-Datum2022
DOIs
PublikationsstatusVeröffentlicht - 1 Mai 2023

Schlagwörter

  • quantitative MRI
  • model-based reconstruction

ASJC Scopus subject areas

  • Software
  • Radiologie- und Ultraschalltechnik
  • Elektrotechnik und Elektronik
  • Angewandte Informatik

Kooperationen

  • BioTechMed-Graz

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