The EU H2020 funded project HADRIAN addresses specific challenges of human-systems integration (HSI) to bring together real drivers with complex and smart technologies to form safe, acceptable, and meaningful system outcomes. The HADRIAN (Holistic Approach for Driver Role Integration and Automation Allocation for European Mobility Needs) project investigates the definition of safe and acceptable driver roles for higher levels of automated driving with 16 research and industrial partners. This paper briefly reviews the field of HSI and postulates two dominant challenges for HSI in the domain of automated driving that will be addressed as part of HADRIAN: first, the impact of restricting the search in traditional solution spaces along prevalent organizational boundaries. Secondly, the human factors problems of humans interacting with highly automated systems across various fields. The paper then presents the HADRIAN approach for HSI for this field focusing on (1) human mobility needs as starting and converging point for engineering and research efforts, (2) strengthening holistic system definitions, (3) iterative design combined with risk and opportunity management, and (4) the application of naturalistic research methods including human-in-the-loop simulation.