TY - JOUR
T1 - Semi-Synthetic Polysaccharide Sulfates as Anticoagulant Coatings for PET, 1 - Cellulose Sulfate
AU - Gericke, Martin
AU - Doliška, Aleš
AU - Stana, Jan
AU - Liebert, Tim
AU - Heinze, Thomas
AU - Stana-Kleinschek, Karin
PY - 2011/4/8
Y1 - 2011/4/8
N2 - In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material. Anticoagulant cellulose sulfates, which are easily accessible by homogeneous synthesis in ionic liquids, can be used to improve the blood compatibility of PET-based materials. QCM-D studies revealed that coating with different amino-group-containing polysaccharides can improve the subsequent adsorption of an anticoagulant layer.
AB - In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material. Anticoagulant cellulose sulfates, which are easily accessible by homogeneous synthesis in ionic liquids, can be used to improve the blood compatibility of PET-based materials. QCM-D studies revealed that coating with different amino-group-containing polysaccharides can improve the subsequent adsorption of an anticoagulant layer.
KW - Anticoagulant coatings
KW - Blood compatibility
KW - Cellulose sulfates
KW - Chitosan
KW - Layer-by-layer assemblies
UR - http://www.scopus.com/inward/record.url?scp=79953097088&partnerID=8YFLogxK
U2 - 10.1002/mabi.201000419
DO - 10.1002/mabi.201000419
M3 - Article
C2 - 21254402
AN - SCOPUS:79953097088
SN - 1616-5187
VL - 11
SP - 549
EP - 556
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
IS - 4
ER -