TY - JOUR
T1 - The effect of intermittent mixing on particle heat transfer in an agitated dryer
AU - Chaksmithanont, Prin
AU - McEntee, Gabrielle
AU - Hartmanshenn, Clara
AU - Leung, Carlin
AU - Khinast, Johannes G.
AU - Papageorgiou, Charles D.
AU - Mitchell, Christopher
AU - Quon, Justin L.
AU - Glasser, Benjamin J.
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/5/15
Y1 - 2023/5/15
N2 - Intermittent mixing, alternating agitation and no agitation, is an approach to maintain a high drying rate while minimizing particle breakage in agitated filter drying of the active pharmaceutical ingredient. In this study, the effect of intermittent mixing on heat transfer of particles was examined using DEM simulations. The agitation ratio (the fraction of time the agitator is on) and intermittent cycle number (the number of on/off cycles) represent the extent and allocation of agitation, respectively. It was observed that as the agitation ratio increases from the static bed, the rate of heat transfer and temperature uniformity initially increased sharply, and then more gradually for high agitation ratios. Additionally, the rate of heat transfer and temperature uniformity initially increased with intermittent cycle number, then reached a plateau. The results were fitted using a power law which predicted the rate of heat transfer as a function of the intermittent mixing parameters.
AB - Intermittent mixing, alternating agitation and no agitation, is an approach to maintain a high drying rate while minimizing particle breakage in agitated filter drying of the active pharmaceutical ingredient. In this study, the effect of intermittent mixing on heat transfer of particles was examined using DEM simulations. The agitation ratio (the fraction of time the agitator is on) and intermittent cycle number (the number of on/off cycles) represent the extent and allocation of agitation, respectively. It was observed that as the agitation ratio increases from the static bed, the rate of heat transfer and temperature uniformity initially increased sharply, and then more gradually for high agitation ratios. Additionally, the rate of heat transfer and temperature uniformity initially increased with intermittent cycle number, then reached a plateau. The results were fitted using a power law which predicted the rate of heat transfer as a function of the intermittent mixing parameters.
KW - Agitated dryer
KW - Discrete element method
KW - Heat transfer
KW - Intermittent mixing
UR - http://www.scopus.com/inward/record.url?scp=85150937408&partnerID=8YFLogxK
U2 - 10.1016/j.powtec.2023.118459
DO - 10.1016/j.powtec.2023.118459
M3 - Article
AN - SCOPUS:85150937408
SN - 0032-5910
VL - 422
JO - Powder Technology
JF - Powder Technology
M1 - 118459
ER -