Abstract
We have developed a thermally driven domino reaction for the synthesis of (S)-α-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids.
Originalsprache | englisch |
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Seiten (von - bis) | 1921-1923 |
Seitenumfang | 3 |
Fachzeitschrift | Tetrahedron Letters |
Jahrgang | 54 |
Ausgabenummer | 15 |
DOIs | |
Publikationsstatus | Veröffentlicht - 2013 |