Ultra-small dye-doped silica nanoparticles via modified sol-gel technique

R. Riccò*, S. Nizzero, E. Penna, A. Meneghello, E. Cretaio, F. Enrichi

*Korrespondierende/r Autor/-in für diese Arbeit

Publikation: Beitrag in einer FachzeitschriftArtikelBegutachtung

Abstract

In modern biosensing and imaging, fluorescence-based methods constitute the most diffused approach to achieve optimal detection of analytes, both in solution and on the single-particle level. Despite the huge progresses made in recent decades in the development of plasmonic biosensors and label-free sensing techniques, fluorescent molecules remain the most commonly used contrast agents to date for commercial imaging and detection methods. However, they exhibit low stability, can be difficult to functionalise, and often result in a low signal-to-noise ratio. Thus, embedding fluorescent probes into robust and bio-compatible materials, such as silica nanoparticles, can substantially enhance the detection limit and dramatically increase the sensitivity. In this work, ultra-small fluorescent silica nanoparticles (NPs) for optical biosensing applications were doped with a fluorescent dye, using simple water-based sol-gel approaches based on the classical Stöber procedure. By systematically modulating reaction parameters, controllable size tuning of particle diameters as low as 10 nm was achieved. Particles morphology and optical response were evaluated showing a possible single-molecule behaviour, without employing microemulsion methods to achieve similar results. [Figure not available: see fulltext.].

Originalspracheenglisch
Aufsatznummer117
FachzeitschriftJournal of Nanoparticle Research
Jahrgang20
Ausgabenummer5
DOIs
PublikationsstatusVeröffentlicht - 1 Mai 2018

ASJC Scopus subject areas

  • Bioengineering
  • Atom- und Molekularphysik sowie Optik
  • Chemie (insg.)
  • Modellierung und Simulation
  • Werkstoffwissenschaften (insg.)
  • Physik der kondensierten Materie

Fingerprint

Untersuchen Sie die Forschungsthemen von „Ultra-small dye-doped silica nanoparticles via modified sol-gel technique“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren