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Abstract
In this contribution, we report on the thin-film synthesis of a thermoresponsive polymer onto another polymer used as an enteric coating in drug applications. In particular, we deposit cross-linked poly(N-vinylcaprolactam) (pNVCL) thin films by initiated chemical vapor deposition (iCVD) onto spin-coated Eudragit (EUD) layers. Already upon iCVD synthesis, the layered structure starts to form wrinkles at a minimum iCVD thickness of 30 nm. By changing the EUD layer thickness and the amount of cross-linking used during iCVD, the morphology of the wrinkles is demonstrated to be readily tunable. Laterally, the double-layer structures vary in morphology from being ultrasmooth to exhibiting up to a 3.5 μm wrinkle wavelength. The surface roughness and, thus, the wrinkles' height can be tailored from below 1 nm up to 100 nm. From the resulting wavelength of wrinkles, an estimation of the elastic modulus of pNVCL proves its tunability over a wide range of values thanks to the iCVD process. This study elucidates an uncomplicated way to tune the wrinkles' morphology and, thus, the surface area of a system that can be employed in drug delivery applications. Hence, an enteric coating of EUD together with an iCVD-synthesized thermoresponsive thin film is proposed as a promising composite encapsulation layer to outperform established systems in terms of tunability of the response to multiple external stimuli.
Originalsprache | englisch |
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Seiten (von - bis) | 24165-24171 |
Seitenumfang | 7 |
Fachzeitschrift | The Journal of Physical Chemistry C |
Jahrgang | 123 |
Ausgabenummer | 39 |
DOIs | |
Publikationsstatus | Veröffentlicht - 3 Okt. 2019 |
ASJC Scopus subject areas
- Elektronische, optische und magnetische Materialien
- Energie (insg.)
- Physikalische und Theoretische Chemie
- Oberflächen, Beschichtungen und Folien
Kooperationen
- NAWI Graz
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Thermo-Responsiveness Linked to Deposition Conditions in Initiated Chemical Vapor Deposition of Smart Hydrogel Thin Films for Sensor Applications
Fabian Tobias Muralter (Redner/in)
3 Dez. 2019Aktivität: Vortrag oder Präsentation › Vortrag bei Konferenz oder Fachtagung › Science to science