Description
Biomechanical testing of brain tissue together with the associated computational modeling can provide important insights into the underlying mechanisms of brain injuries, cerebral pathologies and neurological disorders. Understanding and characterizing the mechanical and structural properties of this complex tissue is essential for the development and calibration of reliable models. Recently, a novel nonlinear poro-viscoelastic computational model has been proposed that is capable to capture the mechanical response of the tissue under various loading conditions. This description enables the examination of a wide range of intrinsic material parameters. The current study focuses on the experimental investigation of the sensitivity of these parameters using tailor-made tissue-mimicking hydrogels and porcine brain tissue. In particular, the influence of the intrinsic permeability is studied in order to gain further knowledge about the coupling of viscous and porous effects in the mechanical behavior of brain tissue. Mechanical responses are captured over wide loading ranges by deploying confined compression, consolidation and indentation tests. The interaction between fluid and solid phase on a macroscopic scale is investigated using swelling experiments (free and confined). The microstructure and morphology are investigated with light microscopy and cryogenic scanning electron microscopy (cryo-SEM).| Period | 5 Jul 2022 |
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| Event title | 11th European Solid Mechanics Conference: ESMC 2022 |
| Event type | Conference |
| Location | Galway, IrelandShow on map |
| Degree of Recognition | International |