Martin Simon Thonhofer

Research output

Research output per year 2010 2013 2014 2015 2016 2017 2025

• 29 Article
• 26 Poster
• 17 (Old data) Lecture or Presentation
• 1 Abstract
• 1 More
  • 1 Patent

Research output per year

Research output per year

Search results

• 2025

  A remarkable change in inhibition potency and selectivity of isofagomine by simple N-modification

  Culum, A., Prasch, H., Dorn, T., Fischer, R., Gardić, E., Schmutz, F., Steinbrugger, M., Stütz, A. E., Weber, P., Wrodnigg, T. M. & Thonhofer, M., Jan 2025, In: Monatshefte fur Chemie. 156, 1, p. 21-34 14 p., e202300480.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucosidase 100%
  • Derivatization 33%
  • Glycoside Hydrolase 33%
  • Galactosidase 33%
  • Canavalia ensiformis 33%

• Covalent modification of chitosan surfaces with a sugar amino acid and lysine analogues

  Dorn, T., Stana Kleinschek, K., Steindorfer, T. A., Thonhofer, M. S., Wrodnigg, T. M. & Kargl, R., Jan 2025, In: Monatshefte fur Chemie. 156, 1, p. 65-75 11 p., 117487.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Covalent Modification 100%
  • Hydrolase Inhibitor 20%
• 2024

  A concise synthetic approach for isoiminosugars

  Thonhofer, M. S., Culum, A. S., Dorn, T., Fischer, R. C., Prasch, H. A., Stütz, A., Weber, P. & Wrodnigg, T. M., Oct 2024, In: Carbohydrate Research. 544, p. 1-5 5 p., 109239.

  Research output: Contribution to journal › Article › peer-review

• Diaminocyclopentane – L-Lysine Adducts: Potent and selective inhibitors of human O-GlcNAcase

  Weber, P., Bojarová, P., Brouzdová, J., Křen, V., Kulik, N., Stütz, A. E., Thonhofer, M. & Wrodnigg, T. M., Jul 2024, In: Bioorganic Chemistry. 148, 107452.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • L-Lysine 100%
  • Bond Length 50%

• N-Methyl-N-Alkylaminocyclopentanes: Powerful and Selective β-d-Glucocerebrosidase Inhibitors

  Weber, P., Fischer, R., Nasseri, S. A., Pabst, B. M., Prasch, H., Stütz, A. E., Thonhofer, M., Withers, S. G., Windischhofer, W. & Wrodnigg, T. M., Apr 2024, In: Helvetica chimica acta. 107, 4, e202300219.

  Research output: Contribution to journal › Article › peer-review

  • Cycloaddition 100%
  • Glycoside Hydrolase 100%
  • Glucosylceramidase 100%
  • Pharmacological Chaperone 25%
  • Gaucher's Disease 25%
• 2023

  Chemical vapor deposition of carbohydrate-based polymers: a proof of concept study

  Materna, P., Illek, D., Unger, K., Thonhofer, M., Wrodnigg, T. M. & Coclite, A. M., May 2023, In: Monatshefte für Chemie - Chemical Monthly. 154, 5, p. 533-541 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thin Films 100%
  • Chemical Vapor Deposition 100%
  • Polymerization 66%
  • Surface (Surface Science) 33%
  • Biomaterial 33%

• Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase

  Weber, P., Mészáros, Z., Bojarová, P., Ebner, M., Fischer, R., Křen, V., Kulik, N., Müller, P., Vlachová, M., Slámová, K., Stütz, A. E., Thonhofer, M., Torvisco, A., Wrodnigg, T. M. & Wolfsgruber, A., Nov 2023, In: Bioorganic Chemistry. 140, 106819.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycosylation 100%
  • Bioactivity 100%
  • Acetyl 100%
  • Transition State 100%
  • phosphorylation 100%

• Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study

  Prasch, H. A., Wolfsgruber, A., Thonhofer, M. S., Culum, A. S., Mandl, C., Zündel, M., Weber, P., Nasseri, S. A., Gonzales-Santana, A., Tegl, G., Nidetzky, B., Gruber, K., Stütz, A., Withers, S. G. & Wrodnigg, T. M., 1 Dec 2023, In: ChemBioChem. 24, 23, e202300480.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chemistry 100%
  • Glycoside Hydrolase 100%
  • formation 33%
  • Catalyst Activity 33%
  • Enzyme Activity 33%
• 2021

  New α-galactosidase-inhibiting aminohydroxycyclopentanes

  Weber, P., Fischer, R., Nasseri, S. A., Stütz, A., Thonhofer, M. S., Withers, S. G., Wolfsgruber, A. & Wrodnigg, T. M., 22 Apr 2021, In: RSC Advances . 11, 26, p. 15943-15951 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Galactosidase 100%
  • Glycoside Hydrolase 66%
  • Cycloaddition 33%
  • Aldose 33%

• Pharmacological Chaperones for β-Galactosidase Related to GM1-Gangliosidosis and Morquio B: Recent Advances

  Stütz, A., Thonhofer, M. S., Weber, P., Wolfsgruber, A. & Wrodnigg, T. M., Nov 2021, In: The Chemical Record. 21, 11, p. 2980-2989 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pharmacological Chaperone 100%
  • Galactosidase 100%
  • GM1 Gangliosidosis 100%
  • Lysosome Storage Disease 33%
  • Diseases 33%

• Water-based carbodiimide mediated synthesis of polysaccharide-amino acid conjugates: Deprotection, charge and structural analysis

  Gürer, F., Kargl, R., Bračič, M., Makuc, D., Thonhofer, M., Plavec, J., Mohan, T. & Stana Kleinschek, K., 1 Sept 2021, In: Carbohydrate Polymers. 267, 118226.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Carbodiimide 100%
  • Cyanamide 100%
  • 1H-13C HMBC 25%
  • Distorsionless Enhancement by Polarisation Transfer 25%
  • Heteronuclear Single Quantum Coherence 25%
• 2020

  All Sugar Based Cellulose Derivatives Synthesized by Azide–Alkyne Click Chemistry

  Koschella, A., Chien, C. Y., Iwata, T., Thonhofer, M. S., Wrodnigg, T. M. & Heinze, T., 1 Jan 2020, In: Macromolecular Chemistry and Physics. 221, 1, 1900343.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nuclear Magnetic Resonance Spectroscopy 100%
  • Fourier Transform Infrared Spectroscopy 100%
  • Cellulose Derivatives 100%

• Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine

  Weber, P., Thonhofer, M. S., Averill, S., Davies, G. J., Gonzalez Santana, A., Müller, P., Nasseri, S. A., Offen, W. A., Pabst, B. M., Paschke, E., Schalli, M., Torvisco Gomez, A., Tschernutter, M., Tysoe, C., Windischhofer, W., Withers, S. G., Wolfsgruber, A., Wrodnigg, T. M. & Stütz, A., 2020, In: Molecules. 25, 17, 25 p., 4025.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cyclopentane 100%

• N-alkylated iminosugar based ligands: Synthesis and inhibition of human lysosomal β-glucocerebrosidase

  Wolfsgruber, A., Thonhofer, M., Weber, P., Nasseri, S. A., Fischer, R., Schalli, M., Stütz, A. E., Withers, S. G. & Wrodnigg, T. M., Oct 2020, In: Molecules. 25, 20, 4618.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chemistry 100%
  • Nitrile 100%
  • Azide 100%
  • Benzoic Acid 100%
  • Alkyne 100%
• 2019

  Aspects of structural order in 209Bi-containing particles for potential MRI contrast agents based on quadrupole enhanced relaxation

  Scharfetter, H., Gösweiner, C., Krassnig, P. J., Sampl, C., Thonhofer, M. S., Fischer, R., Spirk, S., Kargl, R., Stana Kleinschek, K., Umut, E. & Kruk, D., 2019, In: Molecular Physics. 117, 7-8, p. 935-943 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nuclear Magnetic Resonance Imaging Agent 100%

• Carbohydrates@MOFs

  Astria, E., Thonhofer, M. S., Ricco, R., Liang, W., Angela, C., Tarzia, A., Alt, K., Hagemeyer, C., Rattenberger, J., Schröttner, H., Wrodnigg, T. M., Amenitsch, H., Huang, D., Doonan, C. & Falcaro, P., 1 Jun 2019, In: Materials Horizons. 6, 5, p. 969-977 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Functional dextran amino acid ester particles derived from N-protected S-trityl-L-cysteine

  Bratuša, A., Elschner, T., Heinze, T., Fröhlich, E., Hribernik, S., Božič, M., Žagar, E., Stana Kleinschek, K., Thonhofer, M. S. & Kargl, R., 1 Sept 2019, In: Colloids and Surfaces B: Biointerfaces. 181, p. 561-566 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Amino Acid Ester 100%
  • L-Cysteine 100%
  • Amino Acid Derivative 50%
  • 13C NMR Spectroscopy 33%

• Tris(2-Methoxyphenyl)bismuthine polymorphism characterized by nuclear quadrupole resonance spectroscopy

  Scharfetter, H., Fischer, R., Krassnig, P., Thonhofer, M., Theyer, F. & Gösweiner, C., 1 Sept 2019, In: Crystals. 9, 9, 446.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coolant 100%
• 2017

  A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors

  Lebl, R., Thonhofer, M., Tysoe, C., Pabst, B. M., Schalli, M., Weber, P., Paschke, E., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2017, In: Carbohydrate Research. 442, p. 31-40

  Research output: Contribution to journal › Article › peer-review

  • Baylis-Hillman Reaction 100%
  • Glycosidase Inhibitor 100%
  • Intramolecular Ring Closure 50%
  • Hydroboration 50%
  • Epimer 50%

• A new type of pharmacological chaperone for GM1-gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols.

  Schalli, M., Weber, P., Tysoe, C., Pabst, B. M., Thonhofer, M., Paschke, E., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2017, In: Bioorganic & Medicinal Chemistry Letters. 27, 15, p. 3431-3435

  Research output: Contribution to journal › Article › peer-review

  • Pharmacological Chaperone 100%
  • Galactosidase 100%
  • GM1 Gangliosidosis 100%
  • Lysosome Storage Disease 33%

• C-5a-substituted validamine type glycosidase inhibitors.

  Schalli, M., Wolfsgruber, A., Gonzalez Santana, A., Tysoe, C., Fischer, R., Stütz, A., Thonhofer, M. & Withers, S. G., 2017, In: Carbohydrate Research. 440-441, p. 1-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycosidase Inhibitor 100%
  • Glucosidase 50%
  • Glycosidase 50%

• N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a GM1-gangliosidosis related human lysosomal β-galactosidase mutant.

  Schalli, M., Tysoe, C., Fischer, R., Pabst, B. M., Thonhofer, M., Paschke, E., Rappitsch, T., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2017, In: Carbohydrate Research. 443-444, p. 15-22 8 p.

  Research output: Contribution to journal › Article › peer-review
• 2016

  From secondary alcohols to tertiary fluoro substituents: A simple route to hydroxymethyl branched sugars with a fluorine substituent at the branching point

  Schalli, M., Thonhofer, M., Wolfsgruber, A., Weber, H., Fischer, R., Saf, R. & Stütz, A., 2016, In: Carbohydrate Research. 436, p. 11-19

  Research output: Contribution to journal › Article › peer-review

  • Wittig Reaction 100%
  • Enol Ether 100%
  • Phosphorane 100%
  • Hydroxymethyl Group 100%

• Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.

  Thonhofer, M., Weber, P., Santana, A. G., Fischer, R., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2016, In: Bioorganic & Medicinal Chemistry Letters. 26, 5, p. 1438-1442 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Galactosidase 100%
  • 1 Deoxymannonojirimycin 33%

• Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C.

  Thonhofer, M., Weber, P., Gonzalez Santana, A., Tysoe, C., Fischer, R., Pabst, B. M., Paschke, E., Schalli, M., Stütz, A., Tschernutter, M., Windischhofer, W. & Withers, S. G., 2016, In: Carbohydrate Research. 429, p. 71-80 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2015

  5-Fluoro derivatives of 4-epi-isofagomine as D-galactosidase inhibitors and potential pharmacological chaperones for GM1-gangliosidosis as well as Fabry's disease

  Thonhofer, M., Gonzalez Santana, A., Fischer, R., Torvisco Gomez, A., Saf, R., Schalli, M., Stütz, A. & Withers, S. G., Dec 2015, In: Carbohydrate Research. 420, p. 6-12

  Research output: Contribution to journal › Article › peer-review

  • Afegostat 100%
  • Fabry Disease 100%
• 2013

  Yarrowia lipolytica dehydrogenase/reductase: An enzyme tolerant for lipophilic compounds and carbohydrate substrates

  Napora, K., Wrodnigg, T., Kosmus, P., Thonhofer, M., Robins, K. & Winkler, M., 2013, In: Bioorganic & Medicinal Chemistry Letters. 23, 11, p. 3393-3395

  Research output: Contribution to journal › Article › peer-review

  • Ribitol 100%
  • Ribose 100%
  • Yarrowia lipolytica 100%
  • Short Chain Dehydrogenase/Reductase 80%
  • Short-Chain Dehydrogenase 57%
• 2010

  Fluorous Iminoalditols: A New Family of N-Modified Glycosidase Inhibitors

  Schitter, G., Steiner, A., Pototschnig, G., Scheucher, E., Thonhofer, M., Tarling, C., Withers, S., Fantur, K., Paschke, E., Mahuran, D., Rigat, B., Tropak, M., Illaszewicz-Trattner, C., Saf, R., Stütz, A. & Wrodnigg, T., 2010, In: ChemBioChem. 11, 14, p. 2026-2033

  Research output: Contribution to journal › Article › peer-review

• Synthesis of Lipophilic 1-Deoxygalactonojirimycin Derivatives as Galactosidase Inhibitors

  Schitter, G., Scheucher, E., Steiner, A., Stütz, A., Thonhofer, M., Tarling, C., Withers, S., Wicki, J., Fantur, K., Paschke, E., Mahuran, D., Rigat, B., Tropak, M. & Wrodnigg, T., 2010, In: Beilstein Journal of Organic Chemistry . 6, 21, 7 p.

  Research output: Contribution to journal › Article › peer-review