Research output per year
Research output per year
- 43 results
Search results
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2025
Model-based real-time optimization in continuous pharmaceutical manufacturing
Damiri, H. S. R., Steinberger, M., Kuchler, L., Azimi, A., Martinuzzi, S., Sagmeister, P., Williams, J. D., Koch, S., Tranninger, M., Rehrl, J., Celikovic, S., Sacher, S., Kappe, C. O. & Horn, M., Jan 2025, In: Computers and Chemical Engineering. 192, 108915.Research output: Contribution to journal › Article › peer-review
Open Access -
2024
A modeling and control framework for extraction processes
Böhm, J. M., Moser, D., Neugebauer, P., Rehrl, J., Pöchlauer, P., Kirschneck, D., Horn, M., Steinberger, M. & Sacher, S., 5 Oct 2024, In: Chemical Engineering Science. 298, 298, 120384.Research output: Contribution to journal › Article › peer-review
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Real-time prediction of dissolution profiles of coated oral dosage forms
Sacher, S., Fink, E., Alva, C., Alberto Afonso Urich, J., Doğan, A., Herndler, V., Koutsamanis, I., Kushwah, V., Peter, A., Salar-Behzadi, S., Wilfling, K., Stranzinger, S., Zettl, M., Feng, X., Korang-Yeboah, M., Wu, H. & Khinast, J. G., 5 Dec 2024, In: International Journal of Pharmaceutics. 666, 124841.Research output: Contribution to journal › Article › peer-review
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2023
An Integrated Real-time Monitoring and Statistical Process Control Approach for Coating Process and Product Quality via In-line Optical Coherence Tomography
Sacher, S., Fink, E., Herndler, V., Stumptner, W., Peter, A., Zettl, M., Korang-Yeboah, M., Feng, X., Wu, H. & Khinast, J. G., Dec 2023, In: Journal of Pharmaceutical Innovation . 18, 4, p. 1870-1878 9 p.Research output: Contribution to journal › Article › peer-review
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Control of a complex multistep process for the production of mesalazine
Castillo, I., Rehrl, J., Sagmeister, P., Lebl, R., Kruisz, J., Celikovic, S., Sipek, M., Kirschneck, D., Horn, M., Sacher, S., Cantillo, D., Williams, J. D., Khinast, J. G. & Kappe, C. O., Feb 2023, In: Journal of Process Control. 122, p. 59-68 10 p.Research output: Contribution to journal › Article › peer-review
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On the influence of raw material attributes on process behaviour and product quality in a continuous wet granulation tableting line.
Zupančič, O., Doğan, A., Martins Fraga, R., Demiri, V., Paudel, A., Khinast, J. G., Spörk, M. & Sacher, S., 1 Jun 2023, In: International Journal of Pharmaceutics. 642, 123097.Research output: Contribution to journal › Article › peer-review
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Prediction of dissolution performance of uncoated solid oral dosage forms via optical coherence tomography
Fink, E., Celikovic, S., Rehrl, J., Sacher, S., Afonso Urich, J. A. & Khinast, J., Aug 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 189, p. 281-290 10 p.Research output: Contribution to journal › Article › peer-review
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2022
Automated and continuous synthesis of drug substances
Sacher, S., Castillo, I., Rehrl, J., Sagmeister, P., Lebl, R., Kruisz, J., Celikovic, S., Sipek, M., Williams, J. D., Kirschneck, D., Kappe, C. O. & Horn, M., Jan 2022, In: Chemical Engineering Research and Design. 177, p. 493-501 9 p.Research output: Contribution to journal › Article › peer-review
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2021
Advanced Real-Time Process Analytics for Multistep Synthesis in Continuous Flow**
Sagmeister, P., Lebl, R., Castillo, I., Rehrl, J., Kruisz, J., Sipek, M., Horn, M., Sacher, S., Cantillo, D., Williams, J. D. & Kappe, C. O., 6 Apr 2021, In: Angewandte Chemie - International Edition. 60, 15, p. 8139-8148 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Comparative Study of a Novel Micro-feeder and Loss-in-weight Feeders
Sacher, S., Fathollahi, S. & Khinast, J. G., 2021, In: Journal of Pharmaceutical Innovation .Research output: Contribution to journal › Article › peer-review
Open Access -
Development of a Controlled Continuous Low-Dose Feeding Process
Fathollahi, S., Kruisz, J., Sacher, S., Rehrl, J., Escotet-Espinoza, M. S., DiNunzio, J., Glasser, B. J. & Khinast, J. G., Oct 2021, In: AAPS PharmSciTech. 22, 7, 247.Research output: Contribution to journal › Article › peer-review
Open Access -
Feasibility of In-line monitoring of critical coating quality attributes via OCT: Thickness, variability, film homogeneity and roughness
Sacher, S., Peter, A. & Khinast, J. G., Dec 2021, In: International Journal of Pharmaceutics: X. 3, 100067.Research output: Contribution to journal › Article › peer-review
Open Access -
X-ray imaging: A potential enabler of automated particulate detection and cake-structure analysis in lyophilized products?
Sacher, S., Poms, J., Dekner, M., Wallner-Mang, S., Vogt, M., Khinast, J. G. & Schennach, R., Dec 2021, In: International Journal of Pharmaceutics: X. 3, 100101.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
A solution for low-dose feeding in continuous pharmaceutical processes
Sacher, S., Heindl, N., Urich, J. A. A., Kruisz, J. & Khinast, J. G., 15 Dec 2020, In: International Journal of Pharmaceutics. 591, 119969.Research output: Contribution to journal › Article › peer-review
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Model predictive control for continuous pharmaceutical feeding blending units
Celikovic, S., Kirchengast, M., Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., Feb 2020, In: Chemical Engineering Research and Design / A. 154, 154, p. 101-114 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Performance Evaluation of a High-Precision Low-Dose Powder Feeder
Fathollahi, S., Sacher, S., Escotet-Espinoza, M. S., DiNunzio, J. & Khinast, J. G., 3 Nov 2020, In: AAPS PharmSciTech. 21, 8, 301.Research output: Contribution to journal › Article › peer-review
Open Access -
Towards a novel continuous HME-Tableting line: Process development and control concept
Sacher, S., Celikovic, S., Rehrl, J., Poms, J., Kirchengast, M., Kruisz, J., Sipek, M., Salar-Behzadi, S., Berger, H., Stark, G., Horn, M. & Khinast, J. G., 15 Jan 2020, In: European Journal of Pharmaceutical Sciences. 142, 105097.Research output: Contribution to journal › Article › peer-review
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2019
Ensuring Tablet Quality via Model-based Control of a Continuous Direct Compaction Process
Kirchengast, M., Celikovic, S., Rehrl, J., Sacher, S., Kruisz, J., Khinast, J. & Horn, M., 15 Aug 2019, In: International Journal of Pharmaceutics. 2019, 567, p. 1-9 9 p.Research output: Contribution to journal › Article › peer-review
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Improving Pellet Quality in a Pharmaceutical Hot Melt Extrusion Process via PID Control and LOLIMOT-Based MPC
Rehrl, J., Kirchengast, M., Celikovic, S., Sacher, S., Kruisz, J., Khinast, J. & Horn, M., 2019, (E-pub ahead of print) In: Journal of Pharmaceutical Innovation . 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Shedding light on coatings: Real-time monitoring of coating quality at industrial scale
Sacher, S., Wahl, P., Weissensteiner, M., Wolfgang, M., Pokhilchuk, Y., Looser, B., Thies, J., Raffa, A. & Khinast, J. G., 20 Jul 2019, In: International Journal of Pharmaceutics. 566, p. 57-66Research output: Contribution to journal › Article › peer-review
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The need for new control strategies for particulate matter in parenterals
Poms, J., Sacher, S., Nixdorf, M., Dekner, M., Wallner-Mang, S., Janssen, I., Khinast, J. G. & Schennach, R., 3 Jul 2019, In: Pharmaceutical Development and Technology. 24, 6, p. 739-750 12 p.Research output: Contribution to journal › Article › peer-review
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2018
Characterization of the coating and tablet core roughness by means of 3D optical coherence tomography
Markl, D., Wahl, P., Pichler, H., Sacher, S. & Khinast, J., 2018, In: International Journal of Pharmaceutics. 536, 1, p. 459-466Research output: Contribution to journal › Article › peer-review
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Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme
Khinast, J., Schaden, L.-M., Wimmer-Teubenbacher, M., Poms, J., Laggner, P., Lohner, K., Sacher, S. & Salar-Behzadi, S., 2018, In: Pharmaceutical Research. 35, 135.Research output: Contribution to journal › Article › peer-review
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Gluing Pills Technology: A novel route to multilayer tablet manufacturing
Demiri, V., Stranzinger, S., Rinner, P., Piller, M., Sacher, S., Lingitz, J., Khinast, J. & Salar-Behzadi, S., 5 Sept 2018, In: International Journal of Pharmaceutics. 548, 1, p. 672-681 10 p.Research output: Contribution to journal › Article › peer-review
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In-line measurement of residence time distribution in melt extrusion via video analysis
Wahl, P. R., Hörl, G., Kaiser, D., Sacher, S., Rupp, C., Shlieout, G., Breitenbach, J., Koscher, G. & Khinast, J. G., 1 Feb 2018, In: Polymer Engineering and Science. 58, 2, p. 170-179 10 p.Research output: Contribution to journal › Article › peer-review
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Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets
Kreimer, M., Aigner, I., Sacher, S., Krumme, M., Mannschott, T., van der Wel, P., Kaptein, A., Schröttner, H., Brenn, G. & Khinast, J., 2018, In: Powder Technology. 325, p. 247-260Research output: Contribution to journal › Article › peer-review
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2017
A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points
Martinetz, M., Rehrl, J., Aigner, I., Sacher, S. & Khinast, J., 12 May 2017, In: Chemie - Ingenieur - Technik. 89, 8Research output: Contribution to journal › Article › peer-review
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A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules
Laske, S., Paudel, A., Scheibelhofer, O., Sacher, S., Hörmann, T. & Khinast, J., Mar 2017, In: Journal of Pharmaceutical Sciences . 106, 3, p. 667-712 45 p.Research output: Contribution to journal › Article › peer-review
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Continuous monitoring of API content, API distribution and crushing strength after tableting via near-infrared chemical imaging
Wahl, P. R., Pucher, I., Scheibelhofer, O., Kerschhaggl, M., Sacher, S. & Khinast, J. G., 25 Feb 2017, In: International Journal of Pharmaceutics. 518, 1-2, p. 130-137Research output: Contribution to journal › Article › peer-review
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RTD Modeling of a Continuous Dry Granulation Process for Process Control and Materials Diversion
Kruisz, J., Rehrl, J., Sacher, S., Aigner, I., Horn, M. & Khinast, J., 2017, In: International Journal of Pharmaceutics. 528, 1-2, p. 334–344Research output: Contribution to journal › Article › peer-review
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2016
Monitoring of a Hot Melt Coating Process via a Novel Multipoint Near-Infrared Spectrometer
Hohl, R., Scheibelhofer, O., Stocker, E., Salar-Behzadi, S., Haack, D., Koch, K., Kerschhaggl, P., Lochmann, D., Sacher, S. & Zimmer, A., 2 Mar 2016, In: AAPS PharmSciTech.Research output: Contribution to journal › Article › peer-review
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Optimized continuous pharmaceutical manufacturing via model-predictive control
Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 16 Jun 2016, In: International Journal of Pharmaceutics. 510, p. 100-115Research output: Contribution to journal › Article › peer-review
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2015
Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography
Markl, D., Zettl, M., Hannesschläger, G., Sacher, S., Leitner, M., Buchsbaum, A. & Khinast, J., 2015, In: Chemical Engineering Science. 125, p. 200-208Research output: Contribution to journal › Article › peer-review
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Designed Blending for Near Infrared Calibration
Scheibelhofer, O., Grabner, B., Bondi, R. W. J., Igne, B., Sacher, S. & Khinast, J., 2015, In: Journal of Pharmaceutical Sciences . 7, 104, p. 2312-2322Research output: Contribution to journal › Article › peer-review
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2014
Automatic correction for window fouling of near infrared probes in fluidised systems
Scheibelhofer, O., Hohl, R., Salar-Behzadi, S., Haack, D., Koch, K., Kerschhaggl, P., Sacher, S., Menezes, J. C. & Khinast, J., 2014, In: Journal of Near Infrared Spectroscopy. 22, 3, p. 229-238Research output: Contribution to journal › Article › peer-review
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In-line quality control of moving objects by means of spectral-domain OCT
Markl, D., Hannesschläger, G., Buchsbaum, A., Sacher, S., Khinast, J. & Leitner, M., 2014, In: Optics and Lasers in Engineering. 59, p. 1-10Research output: Contribution to journal › Article › peer-review
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Near infrared light spectroscopy: Applicability and new developments
Scheibelhofer, O., Sacher, S. & Khinast, J., 2014, In: European Pharmaceutical Review. 19, 1, p. 51-55Research output: Contribution to journal › Article
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Optical coherence tomography: An Alternative Methodology to Monitor Pharmaceutical Coating Processes
Markl, D., Sacher, S. & Khinast, J., 2014, In: GIT Laboratory Journal Europe. 7, p. 17-22Research output: Contribution to journal › Article
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Optical coherence tomography as a novel tool for in-line monitoring of a pharmaceutical film-coating process
Markl, D., Hannesschläger, G., Sacher, S., Leitner, M. & Khinast, J., 2014, In: European Journal of Pharmaceutical Sciences. 55, p. 58-67Research output: Contribution to journal › Article › peer-review
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PAT for Tableting: Inline Monitoring of API and Excipients via NIR Spectroscopy
Wahl, P., Fruhmann, G., Sacher, S., Straka, G., Sebastian, S. & Khinast, J., 2014, In: European Journal of Pharmaceutics and Biopharmaceutics . 87, 2, p. 271-278Research output: Contribution to journal › Article › peer-review
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Use of mechanistic simulations as a quantitative risk-ranking tool within the quality by design framework
Stocker, E., Toschkoff, G., Sacher, S. & Khinast, J., 2014, In: International Journal of Pharmaceutics. 475, 1-2, p. 245–255Research output: Contribution to journal › Article › peer-review
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2005
Investigation of different crystal habits without chemical additives in a three-phase reactor
Sacher, S. & Krammer, G., 2005, In: Chemical Engineering Science. 60, 22, p. 6307-6312Research output: Contribution to journal › Article › peer-review
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Untersuchung von Kristallisationsprozessen in einem Ultraschall-Levitator
Sacher, S. & Krammer, G., 2005, In: Chemie - Ingenieur - Technik. 77, 3, p. 290-294Research output: Contribution to journal › Article › peer-review