To identify mechanism(s) by which Troglitazone improves insulin resistance we will study the effects of Troglitazone on lipid metabolism in obese Zucker rats. Our specific goals are: 1) is to assess lipolysis during euglycemic conditions in lean and obese Zucker rats and obese Zucker rats treated with Troglitazone; and 2) to estimate glucose turnover rates in obese Zucker rats treated with Troglitazone during euglycemic conditions and elevated FFA levels.
|Effective start/end date||1/03/99 → 31/12/02|
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