A modeling and control framework for extraction processes

Joscha Martin Böhm, Daniel Moser, Peter Neugebauer, Jakob Rehrl, Peter Pöchlauer, Dirk Kirschneck, Martin Horn, Martin Steinberger*, Stephan Sacher*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Many continuously operated pharmaceutical process routes have been presented recently. Most of these cover the synthesis of the active pharmaceutical ingredient (API) or solid dosage processing. However, the API purification is also gaining attraction. One widespread and waste-intensive unit operation for purification is the liquid–liquid-extraction (LLE). In continuous manufacturing active process control is required, especially for fast processes. Control concepts must be able to react on product quality deviations caused by disturbances or inadequate process settings in real-time. In this study different control concepts for LLE were developed for an extraction column and a multistage extraction. A universally applicable process model was derived and parametrized. The impact of several control concepts including different real-time measurements was evaluated in simulation for both LLE process routes. The results show that simulation tools based on proper process models can support the selection of the most efficient process route and of suitable control concepts.
Original languageEnglish
Article number120384
JournalChemical Engineering Science
Volume298
Issue number298
DOIs
Publication statusPublished - 5 Oct 2024

Keywords

  • continuous manufacturing
  • Liquid-Liquid Extraction
  • process modeling
  • process control
  • Control concept
  • Model-based control
  • Process modeling
  • Advanced process control
  • Continuous manufacturing
  • Liquid–liquid-extraction

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering
  • Industrial and Manufacturing Engineering

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