A scalable process to produce lipid-based compartmented: Janus nanoparticles with pharmaceutically approved excipients

Tri Truong-Cong, Elodie Millart, Le Tuyet Chau Tran, Heinz Amenitsch, Ghislaine Frebourg, Sylviane Lesieur, Vincent Faivre*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


In the field of nanotechnologies, theranostic approaches and fixed-dose combination products require the development of innovative carriers able to co-encapsulate several entities of interest. This communication describes the preparation and characterization of lipid-based Janus compartmented nanoparticles. They were successfully prepared using a scalable process with pharmaceutically approved excipients. The analysis of the microscopic structure and supramolecular organization demonstrated the formation of two physico-chemically different compartments enabling the co-administration at once of both liposoluble and hydrosoluble active pharmaceutical ingredients.

Original languageEnglish
Pages (from-to)3654-3662
Number of pages9
Issue number8
Publication statusPublished - 28 Feb 2018

ASJC Scopus subject areas

  • Materials Science(all)

Fields of Expertise

  • Human- & Biotechnology

Cite this