Analytical determination of bisphenol A (BPA) and bisphenol analogues in paper products by LC-MS/MS

Andrea Jurek, Erich Leitner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


In this study a sensitive analytical method based on liquid chromatography-electrospray tandem mass spectrometry (LC-MS/MS) was developed for the simultaneous analysis of bisphenol A (BPA), bisphenol AF (BPAF), bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF) and bisphenol S in different paper and board products, including virgin fibre samples and recycled samples. Analytes were extracted from the paper matrix using a simple solvent extraction and chromatographic separation was performed on a C18 core-shell (100 mm x 2.1 mm i.d.; 1.7 µm particle size) column. The developed method showed good linearity (R2 > 0.9921) for all analytes. Absolute recoveries ranged from 71 to 115% and precision in terms of reproducibility and repeatability (intra- and inter-day) yielded in relative standard deviations (RSDs) of less than 15.0% and 17.4%, respectively. The limit of detection (LOD) and limit of quantification (LOQ) for the different analytes ranged from 0.29 to 0.40 µg kg−1 paper and from 1.09 to 1.32 µg kg−1 paper, being in the same range for all analytes. Quantitation of the analytes was performed using the internal standard procedure, with concentrations of < LOQ to 9599 µg kg−1 for the different analytes. Furthermore, a calculation of the maximum migration, assuming the ‘worst case’ scenario of 100% migration was performed.

Original languageEnglish
JournalFood Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
Early online date10 Oct 2018
Publication statusPublished - 2 Nov 2018


  • Bisphenol A (BPA)
  • bisphenol analogues
  • food packaging
  • liquid chromatography-tandem mass spectrometry (LC-MS/MS)
  • paper and cardboard

ASJC Scopus subject areas

  • Food Science
  • Chemistry(all)
  • Toxicology
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fields of Expertise

  • Advanced Materials Science
  • Human- & Biotechnology

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