Abstract
This article discusses the arylmalonate decarboxylase (AMDase)-catalyzed desymmetrization of α-aryl-α-Me malonic acids which gives rise to profens such as Naproxen and Flurbiprofen in up to 100% theor. yield. The racemization of profens using an AMDase mutant is also reported. It shows that the AMDase can be used for the prodn. of hydroxy acids and non-proteinogenic amino acids. [on SciFinder(R)]
Original language | English |
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Pages | 274-280 |
Number of pages | 7 |
Publication status | Published - 2012 |
Keywords
- arylmalonate decarboxylase decarboxylation Naproxen