Capsule filling process‐induced tribo‐charging behaviour of HPMC and gelatin capsules with different external lubricants

Thomas Wutscher, Sarah Zellnitz, Mirjam Kobler, Francesca Buttini, Laura Andrade, Veronica Daza, Alberto Mercandelli, Stefano Biserni, Susana Ecenarro Probst, Johannes Khinast, Amrit Paudel

Research output: Contribution to journalAbstractpeer-review


Hard capsules for dry powder inhalation (DPI) are treated with an external lubricant in order to improve their flow properties and to prevent them from sticking together during storage. There are different external lubricants in commercial use, which can lead to differences in flow and processability, such as tribocharging, , widely known as an issue that can occur during capsule filling due to the interaction of capsule surface and capsule filling machine. The tribo‐electric effect of insulator‐metal contacts is a complex phenomenon that still lacks sufficient scientific understanding Therefore, this study aimed to examine the charging behaviour of two different capsule materials, which are lubricated with three different substances, during capsule filling at two different relative humidities (RH) and filling speeds. It turned out that the charge after storage, directly out of the transport aluminium bag, was very low, evidencing in‐process charging. Results proved that lubrication has an impact on the magnitude and the polarity of charge dependent on the capsule material. Tribo‐charging of the capsules was concluded to be a result of the combination of capsule material and lubricant. Generally, capsules showed in‐process charging dependent on the lubricant and capsule material in combination with filling speed and filling humidity when interacting with stainless steel parts of the capsule filling machine
Original languageEnglish
Article number17
Pages (from-to)A7-A7
JournalJournal of Aerosol Medicine and Pulmonary Drug Delivery
Issue number2
Publication statusPublished - 1 Apr 2020

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