TY - JOUR
T1 - Capsule filling process‐induced tribo‐charging behaviour of HPMC and gelatin capsules with different external lubricants
AU - Wutscher, Thomas
AU - Zellnitz, Sarah
AU - Kobler, Mirjam
AU - Buttini, Francesca
AU - Andrade, Laura
AU - Daza, Veronica
AU - Mercandelli, Alberto
AU - Biserni, Stefano
AU - Probst, Susana Ecenarro
AU - Khinast, Johannes
AU - Paudel, Amrit
N1 - Abstracts from The Aerosol Society Drug Delivery to the Lungs, 30th Edinburgh International Conference Centre Edinburgh, Scotland, UK December 11–13, 2019
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Hard capsules for dry powder inhalation (DPI) are treated with an external lubricant in order to improve their flow properties and to prevent them from sticking together during storage. There are different external lubricants in commercial use, which can lead to differences in flow and processability, such as tribocharging, , widely known as an issue that can occur during capsule filling due to the interaction of capsule surface and capsule filling machine. The tribo‐electric effect of insulator‐metal contacts is a complex phenomenon that still lacks sufficient scientific understanding Therefore, this study aimed to examine the charging behaviour of two different capsule materials, which are lubricated with three different substances, during capsule filling at two different relative humidities (RH) and filling speeds. It turned out that the charge after storage, directly out of the transport aluminium bag, was very low, evidencing in‐process charging. Results proved that lubrication has an impact on the magnitude and the polarity of charge dependent on the capsule material. Tribo‐charging of the capsules was concluded to be a result of the combination of capsule material and lubricant. Generally, capsules showed in‐process charging dependent on the lubricant and capsule material in combination with filling speed and filling humidity when interacting with stainless steel parts of the capsule filling machine
AB - Hard capsules for dry powder inhalation (DPI) are treated with an external lubricant in order to improve their flow properties and to prevent them from sticking together during storage. There are different external lubricants in commercial use, which can lead to differences in flow and processability, such as tribocharging, , widely known as an issue that can occur during capsule filling due to the interaction of capsule surface and capsule filling machine. The tribo‐electric effect of insulator‐metal contacts is a complex phenomenon that still lacks sufficient scientific understanding Therefore, this study aimed to examine the charging behaviour of two different capsule materials, which are lubricated with three different substances, during capsule filling at two different relative humidities (RH) and filling speeds. It turned out that the charge after storage, directly out of the transport aluminium bag, was very low, evidencing in‐process charging. Results proved that lubrication has an impact on the magnitude and the polarity of charge dependent on the capsule material. Tribo‐charging of the capsules was concluded to be a result of the combination of capsule material and lubricant. Generally, capsules showed in‐process charging dependent on the lubricant and capsule material in combination with filling speed and filling humidity when interacting with stainless steel parts of the capsule filling machine
U2 - 10.1089/jamp.2020.ab01.abstracts
DO - 10.1089/jamp.2020.ab01.abstracts
M3 - Abstract
SN - 1941-2711
VL - 33
SP - A7-A7
JO - Journal of Aerosol Medicine and Pulmonary Drug Delivery
JF - Journal of Aerosol Medicine and Pulmonary Drug Delivery
IS - 2
M1 - 17
ER -