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Oxidation of the primary alcohol group in the kanamycin A derivative 2 b with simultaneous P-elimination gave the a$-unsaturated aldehyde 3 a of which the derivatives 3 b - e were prepared by acetalisation, oxidation, or reduction. Hydrogenation of the double bond led to 4"-deoxy-5"- epi-kanarnycin A derivatives.
|Translated title of the contribution||Chemical Modification of Kanamycin A. - Derivatives Containing a 4,J-Double Bond in the Kanosamine Part|
|Journal||Liebigs Annalen der Chemie (1979 - 1994)|
|Publication status||Published - 1985|