Chemische Modifizierung von Kanamycin A. Derivate mit 4,5-Doppelbindung im Kanosamin-Teil

Rainer Albert; Karl Dax; Norbert Gassner; Arnold Stütz; Hans Weidmann

Chemische Modifizierung von Kanamycin A. Derivate mit 4,5-Doppelbindung im Kanosamin-Teil

Translated title of the contribution: Chemical Modification of Kanamycin A. - Derivatives Containing a 4,J-Double Bond in the Kanosamine Part

Rainer Albert, Karl Dax, Norbert Gassner, Arnold Stütz, Hans Weidmann

Institute of Organic Chemistry (6410)

Research output: Contribution to journal › Article › peer-review

Abstract

Oxidation of the primary alcohol group in the kanamycin A derivative 2 b with simultaneous P-elimination gave the a$-unsaturated aldehyde 3 a of which the derivatives 3 b - e were prepared by acetalisation, oxidation, or reduction. Hydrogenation of the double bond led to 4"-deoxy-5"- epi-kanarnycin A derivatives.

Translated title of the contribution	Chemical Modification of Kanamycin A. - Derivatives Containing a 4,J-Double Bond in the Kanosamine Part
Original language	German
Pages (from-to)	644-649
Journal	Liebigs Annalen der Chemie (1979 - 1994)
Volume	1985
Issue number	3
Publication status	Published - 1985

Novel Antibiotics
Wrodnigg, T., Steiner, A. & Stütz, A.
1/01/98 → 31/01/03
Project: Research project

Cite this

@article{64ab8c61e3154613b01f13a3cdbcbf33,

title = "Chemische Modifizierung von Kanamycin A. Derivate mit 4,5-Doppelbindung im Kanosamin-Teil",

abstract = "Oxidation of the primary alcohol group in the kanamycin A derivative 2 b with simultaneous P-elimination gave the a$-unsaturated aldehyde 3 a of which the derivatives 3 b - e were prepared by acetalisation, oxidation, or reduction. Hydrogenation of the double bond led to 4{"}-deoxy-5{"}- epi-kanarnycin A derivatives.",

author = "Rainer Albert and Karl Dax and Norbert Gassner and Arnold St{\"u}tz and Hans Weidmann",

year = "1985",

language = "deutsch",

volume = "1985",

pages = "644--649",

journal = "Liebigs Annalen der Chemie (1979 - 1994)",

issn = "0170-2041",

publisher = "VCH Verlagsgesellschaft",

number = "3",

}

TY - JOUR

T1 - Chemische Modifizierung von Kanamycin A. Derivate mit 4,5-Doppelbindung im Kanosamin-Teil

AU - Albert, Rainer

AU - Dax, Karl

AU - Gassner, Norbert

AU - Stütz, Arnold

AU - Weidmann, Hans

PY - 1985

Y1 - 1985

N2 - Oxidation of the primary alcohol group in the kanamycin A derivative 2 b with simultaneous P-elimination gave the a$-unsaturated aldehyde 3 a of which the derivatives 3 b - e were prepared by acetalisation, oxidation, or reduction. Hydrogenation of the double bond led to 4"-deoxy-5"- epi-kanarnycin A derivatives.

AB - Oxidation of the primary alcohol group in the kanamycin A derivative 2 b with simultaneous P-elimination gave the a$-unsaturated aldehyde 3 a of which the derivatives 3 b - e were prepared by acetalisation, oxidation, or reduction. Hydrogenation of the double bond led to 4"-deoxy-5"- epi-kanarnycin A derivatives.

M3 - Artikel

SN - 0170-2041

VL - 1985

SP - 644

EP - 649

JO - Liebigs Annalen der Chemie (1979 - 1994)

JF - Liebigs Annalen der Chemie (1979 - 1994)

IS - 3

ER -

Chemische Modifizierung von Kanamycin A. Derivate mit 4,5-Doppelbindung im Kanosamin-Teil

Abstract

Projects

Novel Antibiotics

Cite this