Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

Melissa Horvat, Victoria Weilch, Robert Rädisch, Sebastian Hecko, Astrid Schiefer, Florian Rudroff, Birgit Wilding, Norbert Klempier, Miroslav Patek, Ludmila Martínková, Margit Winkler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.
Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalCatalysis Science & Technology
Issue number1
Publication statusPublished - 7 Jan 2022

ASJC Scopus subject areas

  • Catalysis

Fields of Expertise

  • Human- & Biotechnology


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