Abstract
UNLABELLED: CLARE is a computational method designed to reveal sequence encryption of tissue-specific regulatory elements. Starting with a set of regulatory elements known to be active in a particular tissue/process, it learns the sequence code of the input set and builds a predictive model from features specific to those elements. The resulting model can then be applied to user-supplied genomic regions to identify novel candidate regulatory elements. CLARE's model also provides a detailed analysis of transcription factors that most likely bind to the elements, making it an invaluable tool for understanding mechanisms of tissue-specific gene regulation.
AVAILABILITY: CLARE is freely accessible at http://clare.dcode.org/.
Original language | English |
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Pages (from-to) | 581-3 |
Number of pages | 3 |
Journal | Bioinformatics |
Volume | 28 |
Issue number | 4 |
DOIs | |
Publication status | Published - 15 Feb 2012 |
Externally published | Yes |
Keywords
- Animals
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Genomics
- Humans
- Mice
- Organ Specificity
- Prosencephalon/metabolism
- Regulatory Sequences, Nucleic Acid
- Software
- Transcription Factors/metabolism