Clinical evaluation of in silico planning and real-time simulation of hepatic radiofrequency ablation (ClinicIMPPACT Trial)

Michael Moche, Harald Busse, Jurgen Futterer, Camila A Hinestrosa, Daniel Seider, Philipp Brandmaier, Marina Kolesnik, Sjoerd Jenniskens, Roberto Blanco Sequeiros, Gaber Komar, Mika Pollari, Martin Eibisberger, Horst Rupert Portugaller, Philip Voglreiter, Ronan Flanagan, Panchatcharam Mariappan, Martin Reinhardt

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To evaluate the accuracy and clinical integrability of a comprehensive simulation tool to plan and predict radiofrequency ablation (RFA) zones in liver tumors.
Forty-five patients with 51 malignant hepatic lesions of different origins were included in a prospective multicenter trial. Prior to CT-guided RFA, all patients underwent multiphase CT which included acquisitions for the assessment of liver perfusion. These data were used to generate a 3D model of the liver. The intra-procedural position of the RFA probe was determined by CT and semi-automatically registered to the 3D model. Size and shape of the simulated ablation zones were compared with those of the thermal ablation zones segmented in contrast-enhanced CT images 1 month after RFA; procedure time was compared with a historical control group …
Original languageEnglish
Number of pages9
JournalEuropean Radiology
Publication statusE-pub ahead of print - 2019

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