Cortical oscillations support sampling-based computations in spiking neural networks

Agnes Korcsak-Gorzo, Michael G. Müller, Andreas Baumbach, Luziwei Leng, Oliver J. Breitwieser, Sacha J. van Albada, Walter Senn, Karlheinz Meier, Robert Legenstein, Mihai A. Petrovici

Research output: Contribution to journalArticlepeer-review


Being permanently confronted with an uncertain world, brains have faced evolutionary pressure to represent this uncertainty in order to respond appropriately. Often, this requires visiting multiple interpretations of the available information or multiple solutions to an encountered problem. This gives rise to the so-called mixing problem: since all of these "valid"states represent powerful attractors, but between themselves can be very dissimilar, switching between such states can be difficult. We propose that cortical oscillations can be effectively used to overcome this challenge. By acting as an effective temperature, background spiking activity modulates exploration. Rhythmic changes induced by cortical oscillations can then be interpreted as a form of simulated tempering. We provide a rigorous mathematical discussion of this link and study some of its phenomenological implications in computer simulations. This identifies a new computational role of cortical oscillations and connects them to various phenomena in the brain, such as sampling-based probabilistic inference, memory replay, multisensory cue combination, and place cell flickering.

Original languageEnglish
Article numbere1009753
JournalPLoS Computational Biology
Issue number3
Publication statusPublished - 24 Mar 2022

ASJC Scopus subject areas

  • Genetics
  • Ecology, Evolution, Behavior and Systematics
  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Ecology
  • Computational Theory and Mathematics
  • Modelling and Simulation


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