Projects per year
A subgroup of bacteriophytochromes comprise the so-called PadCs (phytochrome-activated diguanylate cyclases). Typical for these phytochromes, a modular system can be observed as shown below. The Photosensory module (PSM, in violet, blue, green) integrates red light stimulation via its covalently linked biliverdin IXα chromophore [2,3]. This light input is then translated into the fine tuned production of c-di-GMP by the output domain (red) which serves as bacterial second messenger .
Recently, the research field of optogenetics (see box on the right) showed an ever increasing drive to discover new phytochromes with improved light integration and output signal properties. Red light stimulated proteins are especially well suited in these endeavours because this wavelength range can penetrate biological tissue with minimal signal attenuation .
In a recent study by Buhrke et al.  a truncated version of the red light stimulated protein IsPadC showed interesting altered dimerization properties while keeping its beneficial spectral characteristics. This might allow the development of new improved optogentic tools.
|Publication status||Unpublished - 8 Jun 2022|
|Event||1st Scientific Retreat - BioMolStruct - Seggau, Austria|
Duration: 8 Jun 2022 → 9 Jun 2022
|Seminar||1st Scientific Retreat - BioMolStruct|
|Period||8/06/22 → 9/06/22|
- Winkler Lab
Fields of Expertise
- Human- & Biotechnology
FingerprintDive into the research topics of 'Development of novel red light responsive optogenetic tools using the truncated IsPadC protein as template'. Together they form a unique fingerprint.
- 1 Active
1/10/21 → 30/09/25
Project: Research project
- 1 Poster presentation
Development of novel red light responsive optogenetic tools using the truncated IsPadC protein as template8 Jun 2022 → 9 Jun 2022
Activity: Talk or presentation › Poster presentation › Science to science