Does Electrical Stimulation through Nerve Conduits Improve Peripheral Nerve Regeneration? — A Systematic Review

Sophie Hasiba-Pappas*, Lars-P. Kamolz, Hanna Luze, Sebastian P. Nischwitz, Judith Holzer-Geissler, Alexandru Cristian Tuca, Theresa Margarethe Rienmüller, Mathias Polz, Daniel Ziesel, Raimund Winter

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Background: Peripheral nerve injuries affect over 2% of trauma patients and can lead to severe functional impairment and permanent disability. Autologous nerve transplantation is still the gold standard in the reconstruction of nerve defects. For small defects, conduits can be considered for bridging. Lately, the combined use of conduits and electrical stimulation has gained attention in the treatment of peripheral nerve injury. This review aimed to present the currently available data on this topic. Methods: PubMed, Embase, Medline and the Cochrane Library were searched for studies on electrical stimulation through nerve conduits for nerve defects in in vivo studies. Results: Fifteen studies fit the inclusion criteria. All of them reported on the application of nerve conduits combined with stimulation for sciatic nerve gaps in rats. Functional, electrophysiological and histological evaluations showed improved nerve regeneration after electrical stimulation. High variation was observed in the treatment protocols. Conclusion: Electrically stimulated conduits could improve peripheral nerve regeneration in rat models. The combined application of nerve guidance conduits and electrical stimulation shows promising results and should be further evaluated under standardized conditions.
Original languageEnglish
Article number414
JournalJournal of Personalized Medicine
Issue number3
Publication statusPublished - Mar 2023


  • electrical stimulation
  • nerve conduit
  • nerve regeneration
  • peripheral nerve injury
  • plastic surgery
  • sciatic nerve

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Fields of Expertise

  • Human- & Biotechnology

Treatment code (Nähere Zuordnung)

  • Review


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