Effects of disease progression on mechanical stresses in human abdominal aortic aneurysms

Elisabeth Klimstein, Misael Dalbosco, Gerhard Holzapfel

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review


The present study uses finite element (FE) simulations to investigate a three-stage theory on the pathogenesis of abdominal aortic aneurysms (AAAs). The effect of collagen growth and remodeling (G&R) on mechanical wall stresses during dis-ease evolution is investigated. The results show that impaired remodeling during AAA growth leads to an increase in wall stress, indicating a more vulnerable vessel. Conversely, successful G&R of the collagen network results in less stress, suggesting a possible healing process promoted by vascular cells that sense the mechanical changes associated with AAA formation and growth. Overall, the results presented provide valuable insights into the pathogenesis of AAAs.
Original languageEnglish
Title of host publicationProc. Annual Meeting of the Austrian Society for Biomedical Engineering 2021
EditorsGernot R. Müller Putz, Christian Baumgartner
PublisherVerlag der Technischen Universität Graz
ISBN (Electronic) 978-3-85125-826-4
Publication statusPublished - Oct 2021


  • Abdominal aortic aneurysm
  • Finite element method
  • Growth and remodeling

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