Enhanced sustainability with crystallization in continuous flow

At a time of rising raw material and energy prices, as well as growing awareness of the green transition approach, sustainability is becoming an increasingly important issue in the pharmaceutical industry. Research is actively addressing these issues, driven by changing market demands. In this brief review, we present 5 topics that we believe will play an important role in achieving sustainable continuous crystallization in present, and will continue to do so in the future. In particular, this review focuses on the developments made over the past three years towards continuous crystallization of biomolecules, enantioselective crystallization, new crystallizer designs, process integration of continuous crystallization as well as computer-aided process optimization in crystallization and their contribution to the principles of green chemistry and engineering.