Gene and miRNA expression in giant cell arteritis-a concise systematic review of significantly modified studies

Tadeja Kuret; Blaž Burja; Julia Feichtinger; Gerhard G Thallinger; Mojca Frank-Bertoncelj; Katja Lakota; Polona Žigon; Snezna Sodin-Semrl; Saša Čučnik; Matija Tomšič; Alojzija Hočevar

doi:10.1007/s10067-018-4231-y

Gene and miRNA expression in giant cell arteritis-a concise systematic review of significantly modified studies

Tadeja Kuret, Blaž Burja, Julia Feichtinger, Gerhard G Thallinger, Mojca Frank-Bertoncelj, Katja Lakota, Polona Žigon, Snezna Sodin-Semrl, Saša Čučnik, Matija Tomšič, Alojzija Hočevar

Research output: Contribution to journal › Article › peer-review

Abstract

Giant cell arteritis (GCA) is a systemic vasculitis in individuals older than 50 years, characterized by headaches, visual disturbances, painful scalp, jaw claudication, impairment of limb arteries, and systemic inflammation, among other symptoms. GCA diagnosis is confirmed by a positive temporal artery biopsy (TAB) or by imaging modalities. A prominent acute phase response with inflammation is the hallmark of the disease, predominantly targeting large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable tissue markers specific for GCA. Scarce reports have indicated the importance of epigenetics in GCA. The current systematic review reports significantly changed candidate biomarkers in TABs of GCA patients compared to non-GCA patients using qPCR.

Original language	English
Pages (from-to)	307-316
Journal	Clinical Rheumatology
Volume	38
Issue number	2
Early online date	1 Aug 2018
DOIs	https://doi.org/10.1007/s10067-018-4231-y
Publication status	Published - Feb 2019

Access to Document

10.1007/s10067-018-4231-y

Cite this

@article{953bb72c8d3643468e5561ada254f376,

title = "Gene and miRNA expression in giant cell arteritis-a concise systematic review of significantly modified studies",

abstract = "Giant cell arteritis (GCA) is a systemic vasculitis in individuals older than 50 years, characterized by headaches, visual disturbances, painful scalp, jaw claudication, impairment of limb arteries, and systemic inflammation, among other symptoms. GCA diagnosis is confirmed by a positive temporal artery biopsy (TAB) or by imaging modalities. A prominent acute phase response with inflammation is the hallmark of the disease, predominantly targeting large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable tissue markers specific for GCA. Scarce reports have indicated the importance of epigenetics in GCA. The current systematic review reports significantly changed candidate biomarkers in TABs of GCA patients compared to non-GCA patients using qPCR.",

author = "Tadeja Kuret and Bla{\v z} Burja and Julia Feichtinger and Thallinger, {Gerhard G} and Mojca Frank-Bertoncelj and Katja Lakota and Polona {\v Z}igon and Snezna Sodin-Semrl and Sa{\v s}a {\v C}u{\v c}nik and Matija Tom{\v s}i{\v c} and Alojzija Ho{\v c}evar",

year = "2019",

month = feb,

doi = "10.1007/s10067-018-4231-y",

language = "English",

volume = "38",

pages = "307--316",

journal = "Clinical Rheumatology",

issn = "0770-3198",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - Gene and miRNA expression in giant cell arteritis-a concise systematic review of significantly modified studies

AU - Kuret, Tadeja

AU - Burja, Blaž

AU - Feichtinger, Julia

AU - Thallinger, Gerhard G

AU - Frank-Bertoncelj, Mojca

AU - Lakota, Katja

AU - Žigon, Polona

AU - Sodin-Semrl, Snezna

AU - Čučnik, Saša

AU - Tomšič, Matija

AU - Hočevar, Alojzija

PY - 2019/2

Y1 - 2019/2

N2 - Giant cell arteritis (GCA) is a systemic vasculitis in individuals older than 50 years, characterized by headaches, visual disturbances, painful scalp, jaw claudication, impairment of limb arteries, and systemic inflammation, among other symptoms. GCA diagnosis is confirmed by a positive temporal artery biopsy (TAB) or by imaging modalities. A prominent acute phase response with inflammation is the hallmark of the disease, predominantly targeting large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable tissue markers specific for GCA. Scarce reports have indicated the importance of epigenetics in GCA. The current systematic review reports significantly changed candidate biomarkers in TABs of GCA patients compared to non-GCA patients using qPCR.

AB - Giant cell arteritis (GCA) is a systemic vasculitis in individuals older than 50 years, characterized by headaches, visual disturbances, painful scalp, jaw claudication, impairment of limb arteries, and systemic inflammation, among other symptoms. GCA diagnosis is confirmed by a positive temporal artery biopsy (TAB) or by imaging modalities. A prominent acute phase response with inflammation is the hallmark of the disease, predominantly targeting large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable tissue markers specific for GCA. Scarce reports have indicated the importance of epigenetics in GCA. The current systematic review reports significantly changed candidate biomarkers in TABs of GCA patients compared to non-GCA patients using qPCR.

U2 - 10.1007/s10067-018-4231-y

DO - 10.1007/s10067-018-4231-y

M3 - Article

C2 - 30069799

SN - 0770-3198

VL - 38

SP - 307

EP - 316

JO - Clinical Rheumatology

JF - Clinical Rheumatology

IS - 2

ER -