Human Enzymes for Organic Synthesis

Margit Winkler; Martina Geier; Steven P Hanlon; Bernd Nidetzky; Anton Glieder

doi:10.1002/anie.201800678

Human Enzymes for Organic Synthesis

Margit Winkler, Martina Geier, Steven P Hanlon, Bernd Nidetzky, Anton Glieder

Research output: Contribution to journal › Review article › peer-review

Abstract

Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.

Original language	English
Pages (from-to)	13406-13423
Number of pages	18
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	41
DOIs	https://doi.org/10.1002/anie.201800678 https://doi.org/10.1002/anie.201800678
Publication status	Published - 2018

Fields of Expertise

Human- & Biotechnology

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1 Finished

EU - ROBOX - Expanding the industrial use of Robust Oxidative Biocatalysts for the conversion and production of alcohols (ROBOX)
Glieder, A.
1/04/15 → 31/03/19
Project: Research project

Cite this

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title = "Human Enzymes for Organic Synthesis",

abstract = "Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.",

author = "Margit Winkler and Martina Geier and Hanlon, {Steven P} and Bernd Nidetzky and Anton Glieder",

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T1 - Human Enzymes for Organic Synthesis

AU - Winkler, Margit

AU - Geier, Martina

AU - Hanlon, Steven P

AU - Nidetzky, Bernd

AU - Glieder, Anton

PY - 2018

Y1 - 2018

N2 - Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.

AB - Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.

U2 - 10.1002/anie.201800678

DO - 10.1002/anie.201800678

M3 - Review article

C2 - 29600541

SN - 1433-7851

VL - 57

SP - 13406

EP - 13423

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 41

ER -

Human Enzymes for Organic Synthesis

Abstract

Fields of Expertise

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Projects

EU - ROBOX - Expanding the industrial use of Robust Oxidative Biocatalysts for the conversion and production of alcohols (ROBOX)

Cite this