Initiated chemical vapor deposition of crosslinked organic coatings for controlling gentamicin delivery

Gianfranco Decandia; Fabio Palumbo; Annalisa Treglia; Vincenza Armenise; Pietro Favia; Federico Baruzzi; Katrin Unger; Alberto Perrotta; Anna Maria Coclite

doi:10.3390/pharmaceutics12030213

Initiated chemical vapor deposition of crosslinked organic coatings for controlling gentamicin delivery

Gianfranco Decandia, Fabio Palumbo^*, Annalisa Treglia, Vincenza Armenise, Pietro Favia, Federico Baruzzi, Katrin Unger, Alberto Perrotta, Anna Maria Coclite

^*Corresponding author for this work

Institute of Solid State Physics (5130)

Research output: Contribution to journal › Article › peer-review

Abstract

A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.

Original language	English
Article number	213
Journal	Pharmaceutics
Volume	12
Issue number	3
DOIs	https://doi.org/10.3390/pharmaceutics12030213
Publication status	Published - Mar 2020

Keywords

Antibacterial test
Drug delivery
Initiated chemical vapour deposition
Poly(methyl methacrylate) (PMMA) copolymer

ASJC Scopus subject areas

Pharmaceutical Science

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10.3390/pharmaceutics12030213

Cite this

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abstract = "A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.",

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author = "Gianfranco Decandia and Fabio Palumbo and Annalisa Treglia and Vincenza Armenise and Pietro Favia and Federico Baruzzi and Katrin Unger and Alberto Perrotta and Coclite, {Anna Maria}",

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AU - Decandia, Gianfranco

AU - Palumbo, Fabio

AU - Treglia, Annalisa

AU - Armenise, Vincenza

AU - Favia, Pietro

AU - Baruzzi, Federico

AU - Unger, Katrin

AU - Perrotta, Alberto

AU - Coclite, Anna Maria

PY - 2020/3

Y1 - 2020/3

N2 - A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.

AB - A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.

KW - Antibacterial test

KW - Drug delivery

KW - Initiated chemical vapour deposition

KW - Poly(methyl methacrylate) (PMMA) copolymer

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DO - 10.3390/pharmaceutics12030213

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ER -

Initiated chemical vapor deposition of crosslinked organic coatings for controlling gentamicin delivery

Abstract

Keywords

ASJC Scopus subject areas

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