Model-based real-time optimization in continuous pharmaceutical manufacturing

Hazem Salim Rfifan Damiri*, Martin Steinberger, Lisa Kuchler, Atabak Azimi, Stefano Martinuzzi, Peter Sagmeister, Jason D. Williams, Stefan Koch, Markus Tranninger, Jakob Rehrl, Selma Celikovic, Stephan Sacher, C. Oliver Kappe, Martin Horn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In this work, real-time optimization (RTO) schemes are proposed and applied on a continuous pharmaceutical manufacturing process which consists of three units: synthesis unit, hot melt extrusion unit and direct compaction line. The developed RTO strategies calculate the operating conditions by optimizing the considered objective functions while satisfying the specific constraints. Moreover, the RTO schemes can cope with intentional changes in the process and unintentional changes such as disturbances. Results from simulations and experiments are presented in this work. An advantageous performance is achieved when using the developed schemes.
Original languageEnglish
Article number108915
JournalComputers and Chemical Engineering
Volume192
Early online dateNov 2024
DOIs
Publication statusPublished - Jan 2025

Keywords

  • Continuous pharmaceutical manufacturing
  • Continuous synthesis
  • Direct compaction
  • Real-time optimization

ASJC Scopus subject areas

  • General Chemical Engineering
  • Computer Science Applications

Cooperations

  • NAWI Graz

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