Abstract
In this work, real-time optimization (RTO) schemes are proposed and applied on a continuous pharmaceutical manufacturing process which consists of three units: synthesis unit, hot melt extrusion unit and direct compaction line. The developed RTO strategies calculate the operating conditions by optimizing the considered objective functions while satisfying the specific constraints. Moreover, the RTO schemes can cope with intentional changes in the process and unintentional changes such as disturbances. Results from simulations and experiments are presented in this work. An advantageous performance is achieved when using the developed schemes.
Original language | English |
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Article number | 108915 |
Journal | Computers and Chemical Engineering |
Volume | 192 |
Early online date | Nov 2024 |
DOIs | |
Publication status | Published - Jan 2025 |
Keywords
- Continuous pharmaceutical manufacturing
- Continuous synthesis
- Direct compaction
- Real-time optimization
ASJC Scopus subject areas
- General Chemical Engineering
- Computer Science Applications
Cooperations
- NAWI Graz