Modification of cellulose thin films with lysine moieties: a promising approach to achieve antifouling performance

Thomas Elschner, Matej Bračič, Tamilselvan Mohan, Rupert Kargl, Karin Stana Kleinschek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Thin films of trimethylsilyl cellulose are obtained by spin coating and regenerated to cellulose. The surface is activated with N,N′-carbonyldiimidazole and aminolysis with lysine is carried out in aqueous solution to yield a cellulose lysine carbamate film. The surface is analytically characterized by ATR-IR spectroscopy, zetapotential measurements, contact angle measurements, and atomic force microscopy. The amount of functional groups is determined by pH potentiometric titration as well as the ninhydrin test and is in the range of 25 pmolcm−2. Adsorption of bovine serum albumine (BSA) and fibrinogen on the cellulose film and the cellulose lysine carbamate surface is studied at different pH values by quartz crystal microbalance with dissipation monitoring (QCM-D). The adsorption of BSA is significantly reduced by modification with lysine. At physiological pH value (7.4) the adsorption of fibrinogen is even six times lower (1.0 mgm−2) compared to the pure cellulose surface. Thus, cellulose thin films with lysine moieties are promising candidates for hemo-compatible antifouling surfaces in the field of blood contacting devices.

Original languageEnglish
Pages (from-to)537-547
Number of pages11
Issue number1
Publication statusPublished - 1 Jan 2018
Externally publishedYes


  • BSA
  • Cellulose lysine carbamate
  • Fibrinogen
  • Protein adsorption
  • Thin films

ASJC Scopus subject areas

  • Polymers and Plastics

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