MOFBOTS: Metal–Organic-Framework-Based Biomedical Microrobots

Xiaopu Wang; Xiang Zhong Chen; Carlos C.J. Alcântara; Semih Sevim; Marcus Hoop; Anastasia Terzopoulou; Carmela de Marco; Chengzhi Hu; Andrew J. de Mello; Paolo Falcaro; Shuhei Furukawa; Bradley J. Nelson; Josep Puigmartí-Luis; Salvador Pané

doi:10.1002/adma.201901592

MOFBOTS: Metal–Organic-Framework-Based Biomedical Microrobots

Xiaopu Wang, Xiang Zhong Chen, Carlos C.J. Alcântara, Semih Sevim, Marcus Hoop, Anastasia Terzopoulou, Carmela de Marco, Chengzhi Hu, Andrew J. de Mello, Paolo Falcaro, Shuhei Furukawa, Bradley J. Nelson, Josep Puigmartí-Luis^*, Salvador Pané

^*Corresponding author for this work

Institute of Physical and Theoretical Chemistry (6350)

Research output: Contribution to journal › Article › peer-review

Abstract

Motile metal−organic frameworks (MOFs) are potential candidates to serve as small-scale robotic platforms for applications in environmental remediation, targeted drug delivery, or nanosurgery. Here, magnetic helical microstructures coated with a kind of zinc-based MOF, zeolitic imidazole framework-8 (ZIF-8), with biocompatibility characteristics and pH-responsive features, are successfully fabricated. Moreover, it is shown that this highly integrated multifunctional device can swim along predesigned tracks under the control of weak rotational magnetic fields. The proposed systems can achieve single-cell targeting in a cell culture media and a controlled delivery of cargo payloads inside a complex microfluidic channel network. This new approach toward the fabrication of integrated multifunctional systems will open new avenues in soft microrobotics beyond current applications.

Original language	English
Article number	1901592
Journal	Advanced Materials
Volume	31
Issue number	27
DOIs	https://doi.org/10.1002/adma.201901592
Publication status	Published - 5 Jul 2019

Keywords

drug delivery
metal–organic frameworks
micromachines
pH-responsive materials
ZIF-8

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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title = "MOFBOTS: Metal–Organic-Framework-Based Biomedical Microrobots",

abstract = "Motile metal−organic frameworks (MOFs) are potential candidates to serve as small-scale robotic platforms for applications in environmental remediation, targeted drug delivery, or nanosurgery. Here, magnetic helical microstructures coated with a kind of zinc-based MOF, zeolitic imidazole framework-8 (ZIF-8), with biocompatibility characteristics and pH-responsive features, are successfully fabricated. Moreover, it is shown that this highly integrated multifunctional device can swim along predesigned tracks under the control of weak rotational magnetic fields. The proposed systems can achieve single-cell targeting in a cell culture media and a controlled delivery of cargo payloads inside a complex microfluidic channel network. This new approach toward the fabrication of integrated multifunctional systems will open new avenues in soft microrobotics beyond current applications.",

keywords = "drug delivery, metal–organic frameworks, micromachines, pH-responsive materials, ZIF-8",

author = "Xiaopu Wang and Chen, {Xiang Zhong} and Alc{\^a}ntara, {Carlos C.J.} and Semih Sevim and Marcus Hoop and Anastasia Terzopoulou and {de Marco}, Carmela and Chengzhi Hu and {de Mello}, {Andrew J.} and Paolo Falcaro and Shuhei Furukawa and Nelson, {Bradley J.} and Josep Puigmart{\'i}-Luis and Salvador Pan{\'e}",

year = "2019",

month = jul,

day = "5",

doi = "10.1002/adma.201901592",

language = "English",

volume = "31",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH ",

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T2 - Metal–Organic-Framework-Based Biomedical Microrobots

AU - Wang, Xiaopu

AU - Chen, Xiang Zhong

AU - Alcântara, Carlos C.J.

AU - Sevim, Semih

AU - Hoop, Marcus

AU - Terzopoulou, Anastasia

AU - de Marco, Carmela

AU - Hu, Chengzhi

AU - de Mello, Andrew J.

AU - Falcaro, Paolo

AU - Furukawa, Shuhei

AU - Nelson, Bradley J.

AU - Puigmartí-Luis, Josep

AU - Pané, Salvador

PY - 2019/7/5

Y1 - 2019/7/5

N2 - Motile metal−organic frameworks (MOFs) are potential candidates to serve as small-scale robotic platforms for applications in environmental remediation, targeted drug delivery, or nanosurgery. Here, magnetic helical microstructures coated with a kind of zinc-based MOF, zeolitic imidazole framework-8 (ZIF-8), with biocompatibility characteristics and pH-responsive features, are successfully fabricated. Moreover, it is shown that this highly integrated multifunctional device can swim along predesigned tracks under the control of weak rotational magnetic fields. The proposed systems can achieve single-cell targeting in a cell culture media and a controlled delivery of cargo payloads inside a complex microfluidic channel network. This new approach toward the fabrication of integrated multifunctional systems will open new avenues in soft microrobotics beyond current applications.

AB - Motile metal−organic frameworks (MOFs) are potential candidates to serve as small-scale robotic platforms for applications in environmental remediation, targeted drug delivery, or nanosurgery. Here, magnetic helical microstructures coated with a kind of zinc-based MOF, zeolitic imidazole framework-8 (ZIF-8), with biocompatibility characteristics and pH-responsive features, are successfully fabricated. Moreover, it is shown that this highly integrated multifunctional device can swim along predesigned tracks under the control of weak rotational magnetic fields. The proposed systems can achieve single-cell targeting in a cell culture media and a controlled delivery of cargo payloads inside a complex microfluidic channel network. This new approach toward the fabrication of integrated multifunctional systems will open new avenues in soft microrobotics beyond current applications.

KW - drug delivery

KW - metal–organic frameworks

KW - micromachines

KW - pH-responsive materials

KW - ZIF-8

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MOFBOTS: Metal–Organic-Framework-Based Biomedical Microrobots

Abstract

Keywords

ASJC Scopus subject areas

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