MOFs and Biomacromolecules for Biomedical Applications

Francesco Carraro, Miriam Velasquez Hernandez, Maria de las Mercedes Linares Moreau, Efwita Astria Efwita Astria, Christopher J. Sumby, Christian J. Doonan, Paolo Falcaro*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Recent progress has shown that Metal-organic Frameworks (MOFs) can be integrated with biomacromolecules. Depending on the synthesis protocol used, it is possible to control the spatial localization of the biomacromolecules in or on MOF biocomposites. When biomacromolecules are infiltrated or encapsulated within MOFs, the porous materials were found to form a protective coating around the bioactive entity, thus offering improved stability to non-native external environments that would normally lead to its degradation. When MOF particles are surface functionalized with biomacromolecules either via adsorption or grafting, enhanced targeting capabilities and improved biodistribution were observed. In this book chapter, we examine the principal synthetic methods for the preparation of MOF bio-composites. We discuss the progress toward combining the four main classes of biomacromolecules, such as proteins, carbohydrates, nucleic acids, and lipids, with MOFs, and disclose relevant examples for application to drug delivery, biopreservation, and biosensing. As MOF biocomposites composition has been extended from biomacromolecules to more complex biological systems, including viruses and cells, we illustrate how MOFs can be used for the preparation of protective exoskeletons for potential applications to vaccine transportation/delivery and regenerative medicine.
Original languageEnglish
Title of host publicationMetal-Organic Frameworks in Biomedical and Environmental Field
EditorsPatricia Horcajada Cortés, Sara Rojas Macías
Number of pages54
ISBN (Electronic)978-3-030-63380-6
ISBN (Print)978-3-030-63379-0
Publication statusPublished - 2021


  • Metal-Organic Frameworks
  • MOF
  • Biomedical applications
  • Biomacromolecules

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