Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

Lei Gan; Miriam de J. Velasquez-Hernandez; Anita Emmerstorfer-Augustin; Peter Wied; Heimo Wolinski; Simone Dal Zilio; Marcello Solomon; Weibin Liang; Christian Doonan; Paolo Falcaro

doi:10.1039/d2cc03072a

Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

Lei Gan, Miriam de J. Velasquez-Hernandez, Anita Emmerstorfer-Augustin, Peter Wied, Heimo Wolinski, Simone Dal Zilio, Marcello Solomon, Weibin Liang, Christian Doonan^*, Paolo Falcaro^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Metal-organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).

Original language	English
Pages (from-to)	10004-10007
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	72
DOIs	https://doi.org/10.1039/d2cc03072a
Publication status	Published - 1 Aug 2022

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Chemistry(all)
Catalysis

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10.1039/d2cc03072aLicence: CC BY 3.0

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title = "Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments",

abstract = "Metal-organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).",

author = "Lei Gan and Velasquez-Hernandez, {Miriam de J.} and Anita Emmerstorfer-Augustin and Peter Wied and Heimo Wolinski and {Dal Zilio}, Simone and Marcello Solomon and Weibin Liang and Christian Doonan and Paolo Falcaro",

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doi = "10.1039/d2cc03072a",

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T1 - Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

AU - Gan, Lei

AU - Velasquez-Hernandez, Miriam de J.

AU - Emmerstorfer-Augustin, Anita

AU - Wied, Peter

AU - Wolinski, Heimo

AU - Dal Zilio, Simone

AU - Solomon, Marcello

AU - Liang, Weibin

AU - Doonan, Christian

AU - Falcaro, Paolo

PY - 2022/8/1

Y1 - 2022/8/1

N2 - Metal-organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).

AB - Metal-organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).

UR - http://www.scopus.com/inward/record.url?scp=85136221135&partnerID=8YFLogxK

U2 - 10.1039/d2cc03072a

DO - 10.1039/d2cc03072a

M3 - Article

SN - 1359-7345

VL - 58

SP - 10004

EP - 10007

JO - Chemical Communications

JF - Chemical Communications

IS - 72

ER -

Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

Abstract

ASJC Scopus subject areas

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