New derivatives of bicyclic diamines with antiprotozoal activity

Johanna Faist, Werner Seebacher, Robert Saf, Reto Brun, Marcel Kaiser, Robert Weis

Research output: Contribution to journalArticlepeer-review

Abstract

ω-Aminoacyl and -alkyl derivatives of 4-(dialkylamino)bicyclo[2.2.2]octan-2-amines and of 5-(dialkylamino)-2-azabicyclo[3.2.2]nonanes were prepared and their activities were examined in vitro against the multiresistant K1 strain of Plasmodium falciparum and against Trypanosoma brucei rhodesiense (STIB 900). The results of the biological tests of the newly synthesized compounds were compared with the activities of already synthesized compounds and of drugs in use. Lots of the newly synthesized compounds showed promising antiprotozoal properties and selectivity, some of them exhibited even higher antiplasmodial activity than chloroquine. Structure–activity relationships were discussed.
Original languageEnglish
Pages (from-to)369-381
JournalMonatshefte für Chemie - Chemical Monthly
Volume147
Issue number2
DOIs
Publication statusPublished - 2016

Treatment code (Nähere Zuordnung)

  • Basic - Fundamental (Grundlagenforschung)

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