Aortic dissection is a life-threatening health condition caused by occurrence of a rupture in the innermost layer of aortic wall. Aortic dissection leads to development of a new blood flow region called false lumen. In the current work, several cases of aortic dissections are investigated in 2D idealized geometries taken from . Biochemical model developed by Sorensen et al.  is successfully implemented in OpenFOAM software. Variation of platelets and agonists concentrations are compared with results published in . It is shown that the change in hemodynamic conditions in the false lumen effectively boosts platelet activation and aggregation in special regions. As a consequence, an increase in the likelihood of thrombus formation is expected. These regions are explored and discussed marking recirculation regions as having the highest chance of blood coagulation.  Menichini C., Xu Y. X. Mathematical modelling of thrombus formation in idealized models of aortic dissection: initial findings and potential. J. Math. Biol. 73:1205-1226 (2016).  Sorensen E. N., Burgreen G. W., Wagner W. R. & Antaki J. F. Computational simulation of platelet deposition and activation: I. Model development and properties. Ann Biomed Eng 27, 436–448 (1999).  Sorensen E. N., Burgreen G. W., Wagner W. R. & Antaki J. F. Computational simulation of platelet deposition and activation: II. Results for Poiseuille flow over collagen. Ann Biomed Eng 27, 449–458 (1999).
|Publication status||Published - 2019|