Of Two Make One: The Biosynthesis of Phenazines

Matthias Mentel, Ekta G. Ahuja, Dmitri V. Mavrodi, Rolf Breinbauer, Linda S. Thomashow, Wulf Blankenfeldt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Five easy steps: Phenazines are redox-active bacterial secondary metabolites that possess broad-specificity antibiotic activity and can also play an important role as virulence factors in infectious disease. Their biosynthesis from two molecules of chorismic acid is catalyzed by enzymes encoded in the conserved phz operon.
Original languageEnglish
Pages (from-to)2295-2304
JournalChemBioChem
Volume10
Issue number14
DOIs
Publication statusPublished - 2009

Treatment code (Nähere Zuordnung)

  • Review

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