Optical Coherence Tomography (OCT) for Analyzing in Real-Time the Tablet Coating Variability of a Continuous Drum Coating Process

Matthias Wolfgang, Patrick Wahl, Manuel Zettl, Stephan Sacher, Johannes G. Khinast, Rainer Bastian, Thomas Fränkel

Research output: Contribution to conference(Old data) Lecture or Presentationpeer-review


This study demonstrates an in-line measurement of the coating performance of a continuous drum coater (DRIACONTI-T, Driam GmbH). Process monitoring is performed by an optical coherence tomography (OCT) sensor (OCT Pharma 1D, Phyllon GmbH) providing cross-sectional images of film-coatings in a non-destructive and contactless manner.
OCT measurement and subsequent automatic data analysis is a method to determine the coating thickness from OCT images without the need of chemometric calibration models, based on a known refractive index of the coating materials. OCT was used to obtain the temporal evolution of the quality parameters mean coating thickness, inter-tablet coating variability and intra-tablet coating variability during the coating process. Thereby the influence of spray rate, air temperature and spray pattern pressure on the quality parameters was studied based on a full-factorial DoE. Additionally, the variability of single drum segments of an extended period of time was studied.
Continuous coating, here in the form of small batches, is an important enabler for continuous manufacturing of solid dosage forms. In combination with an in-line OCT system the coating process can be monitored and actively controlled.
Translated title of the contributionOptische Kohärenz Tomographie (OCT) zur Echtzeit-Analyse der Coating-Variabilität eines kontinuierlichen Coating Prozesses
Original languageEnglish
Publication statusPublished - 17 Nov 2016
EventAIChE Annual Meeting 2016 - Hilton, San Francisco, United States
Duration: 14 Nov 201619 Nov 2016


ConferenceAIChE Annual Meeting 2016
Country/TerritoryUnited States
CitySan Francisco


  • Optical Coherence Tomography
  • Tablet coating variability
  • Coating layer uniformity
  • Continuous coating process
  • In-line monitoring


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