Polysaccharide peptide conjugates: Chemistry, properties and applications

Tamilselvan Mohan, Karin Stana Kleinschek, Rupert Kargl*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The intention of this publication is to give an overview on research related to conjugates of polysaccharides and peptides. Dextran, chitosan, and alginate were selected, to cover four of the most often encountered functional groups known to be present in polysaccharides. These groups are the hydroxyl, the amine, the carboxyl, and the acetal functionality. A collection of the commonly used chemical reactions for conjugation is provided. Conjugation, results into distinct properties compared to the parent polysaccharide, and a number of these characteristics are highlighted. This review aims at demonstrating the applicability of said conjugates with a strong emphasis on biomedical applications, drug delivery, biosensing, and tissue engineering. Some suggestions are made for more rigorous chemistries and analytics that could be investigated. Finally, an outlook is given into which direction the field could be developed further. We hope that this survey provides the reader with a comprehensive summary and contributes to the progress of works that aim at synthetically combining two of the main building blocks of life into supramolecular structures with unprecedented biological response.
Original languageEnglish
Article number118875
JournalCarbohydrate Polymers
Publication statusPublished - 15 Mar 2022


  • Amino acid
  • Drug delivery
  • Fluorescence
  • MRI
  • Peptide
  • Photoacoustic imaging
  • Radiolabelling
  • Tissue engineering

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Organic Chemistry

Cite this