Positive attitude, shape, flexibility, addedvalue accessories or "just being different": How to attract a glycosidase

Arnold E. Stütz*, Tanja M. Wrodnigg

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

For nearly half a century, carbohydrate analogues with a basic nitrogen instead of oxygen in the sugar ring, so-called imino sugars (occasionally also addressed as "azasugars") have been known as powerful glycosidase inhibitors. Their profound interactions with the catalytic residues of glycoside hydrolases have made vital impact on our understanding of these enzymes and their finely tuned catalytic machinery. From these interactions, we have also learned and refined our concepts of exploiting glycosidases or means of their inhibition for many purposes. Thus, the old and familiar "pets" amongst the imino sugars as well as many new and novel derivatives have become useful tools, diagnostic compounds and therapeutic agents for glycochemistry and glycobiology.

Original languageEnglish
Title of host publicationCarbohydrate Chemistry
PublisherRoyal Society of Chemistry
Pages120-149
Number of pages30
ISBN (Print)9781849735872
DOIs
Publication statusPublished - 2013

Publication series

NameCarbohydrate Chemistry
Volume39
ISSN (Print)2041-353X
ISSN (Electronic)1465-1963

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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