Purely Sequence based prediction of contact maps and classification of chromosomal compartments with DDA-DNA

The emergence of genome wide chromosome conformation capturing techniques such as HiC has enabled researchers to investigate the crucial role of chromatin folding in gene regulation. DNA folding forms distinct multiscale patterns which become visible in contact maps generated by such experiments. The abundance of information about chromatin architecture contained in the nucleotide sequence alone is still not well understood. Here we present a purely sequence based computational approach DDA-DNA that sifts out the sequence dependencies of genome architecture at 1Mb resolution.