(R)-selective hydroxynitrile lyase variants with a cupin fold having improved substrate scope and the use thereof

ROMANA WIEDNER, (Inventor), KERSTIN STEINER, (Inventor), Anton Glieder (Inventor), HELMUT SCHWAB (Inventor)

Research output: Patent


The present invention relates to an improved recombinant cupin-hydroxynitrile lyase (HNL), which is capable to catalyze the asymmetric cyanohydrin reaction, wherein the recombinant cupin-HNL comprises at least one amino acid substitution, preferably at least three substitutions.

Translated title of the contribution(R)-selective Hydroxynitrillyasevarianten mit einer Cupin-Faltung mit verbessertem Substratumfang, und Verwendung davon
Original languageEnglish
Patent numberEP2955225
IPCC12P 13/ 00 A I
Priority date12/06/14
Publication statusPublished - 16 Dec 2015

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