Recent Advances in Cyanobacterial Biotransformations

Lenny Malihan-Yap, Hanna C. Grimm, Robert Kourist*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Light-driven biotransformations in recombinant cyanobacteria have been explored in recent years for the production of chiral compounds and platform chemicals. In particular, cyanobacteria harboring oxidoreductases proved to be sustainable hosts providing and recycling reducing equivalents and improving the atom economy of the reactions. However, the provision of light in photobioreactors is considered to be the major bottleneck for up-scaling. In this review, genetic tools for generating recombinant cyanobacterial strains and up to date cyanobacterial biotransformations including redesigning of the photosynthetic electron transport chain to increase specific activities are presented. Finally, several photobioreactor geometries to circumvent the light limitation are discussed and some future perspectives are presented.

Original languageEnglish
Pages (from-to)1628-1644
Number of pages17
Issue number11
Publication statusPublished - 19 Nov 2022


  • Biocatalysis
  • Biotransformations
  • Cyanobacteria
  • Photosynthesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering


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