RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells

Verena Schenk; Elisabeth Rossegger; Clemens Ebner; Florian Bangerl; Klaus Reichmann; Björn Hoffmann; Michael Höpfner; Frank Wiesbrock

doi:10.3390/polym6020264

RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells

Verena Schenk, Elisabeth Rossegger, Clemens Ebner, Florian Bangerl, Klaus Reichmann, Björn Hoffmann, Michael Höpfner, Frank Wiesbrock^*

^*Corresponding author for this work

Institute for Chemistry and Technology of Materials (6380)

Research output: Contribution to journal › Article › peer-review

Abstract

Poly(2-oxazoline) networks with varying swelling degrees and varying hydrophilicity can be synthesized from 2-ethyl-2-oxazoline, 2-nonyl-2-oxazoline, 2-9’-decenyl-2-oxazoline and 2,2’-tetramethylene-bis-2-oxazoline in one-pot/one-step strategies. These gels can be loaded with organic molecules, such as fluorescein isothiocyanate, either during the polymerization (covalent attachment of the dye) or according to post-synthetic swelling/deswelling strategies (physical inclusion of the dye). Surface functionalization of ground gels by thiol-ene reactions with cysteine-bearing peptides exhibiting the arginine-glycine-aspartic acid (RGD) motif yields microparticles with enhanced recognition of human cancer cells compared to healthy endothelial cells.

Original language	English
Pages (from-to)	264-279
Journal	Polymers
Volume	6
Issue number	2
DOIs	https://doi.org/10.3390/polym6020264
Publication status	Published - 2014

Fields of Expertise

Advanced Materials Science

Treatment code (Nähere Zuordnung)

Basic - Fundamental (Grundlagenforschung)
Experimental

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/polym6020264Licence: CC BY 3.0

Synthetics methodoloy towards highly-functional poly-oxazolines
Stelzer, F. & Wiesbrock, F.
1/01/14 → 31/12/16
Project: Research project
Synthetic approaches towards functional polymers
Mühlbacher, I., Kelly, A. M., Stelzer, F. & Wiesbrock, F.
1/01/10 → 31/12/13
Project: Research project

Cite this

@article{924c1d8ca47d4cca9e224d44c51866b2,

title = "RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells",

abstract = "Poly(2-oxazoline) networks with varying swelling degrees and varying hydrophilicity can be synthesized from 2-ethyl-2-oxazoline, 2-nonyl-2-oxazoline, 2-9{\textquoteright}-decenyl-2-oxazoline and 2,2{\textquoteright}-tetramethylene-bis-2-oxazoline in one-pot/one-step strategies. These gels can be loaded with organic molecules, such as fluorescein isothiocyanate, either during the polymerization (covalent attachment of the dye) or according to post-synthetic swelling/deswelling strategies (physical inclusion of the dye). Surface functionalization of ground gels by thiol-ene reactions with cysteine-bearing peptides exhibiting the arginine-glycine-aspartic acid (RGD) motif yields microparticles with enhanced recognition of human cancer cells compared to healthy endothelial cells.",

author = "Verena Schenk and Elisabeth Rossegger and Clemens Ebner and Florian Bangerl and Klaus Reichmann and Bj{\"o}rn Hoffmann and Michael H{\"o}pfner and Frank Wiesbrock",

year = "2014",

doi = "10.3390/polym6020264",

language = "English",

volume = "6",

pages = "264--279",

journal = "Polymers ",

publisher = "MDPI AG",

number = "2",

}

TY - JOUR

T1 - RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells

AU - Schenk, Verena

AU - Rossegger, Elisabeth

AU - Ebner, Clemens

AU - Bangerl, Florian

AU - Reichmann, Klaus

AU - Hoffmann, Björn

AU - Höpfner, Michael

AU - Wiesbrock, Frank

PY - 2014

Y1 - 2014

N2 - Poly(2-oxazoline) networks with varying swelling degrees and varying hydrophilicity can be synthesized from 2-ethyl-2-oxazoline, 2-nonyl-2-oxazoline, 2-9’-decenyl-2-oxazoline and 2,2’-tetramethylene-bis-2-oxazoline in one-pot/one-step strategies. These gels can be loaded with organic molecules, such as fluorescein isothiocyanate, either during the polymerization (covalent attachment of the dye) or according to post-synthetic swelling/deswelling strategies (physical inclusion of the dye). Surface functionalization of ground gels by thiol-ene reactions with cysteine-bearing peptides exhibiting the arginine-glycine-aspartic acid (RGD) motif yields microparticles with enhanced recognition of human cancer cells compared to healthy endothelial cells.

AB - Poly(2-oxazoline) networks with varying swelling degrees and varying hydrophilicity can be synthesized from 2-ethyl-2-oxazoline, 2-nonyl-2-oxazoline, 2-9’-decenyl-2-oxazoline and 2,2’-tetramethylene-bis-2-oxazoline in one-pot/one-step strategies. These gels can be loaded with organic molecules, such as fluorescein isothiocyanate, either during the polymerization (covalent attachment of the dye) or according to post-synthetic swelling/deswelling strategies (physical inclusion of the dye). Surface functionalization of ground gels by thiol-ene reactions with cysteine-bearing peptides exhibiting the arginine-glycine-aspartic acid (RGD) motif yields microparticles with enhanced recognition of human cancer cells compared to healthy endothelial cells.

U2 - 10.3390/polym6020264

DO - 10.3390/polym6020264

M3 - Article

VL - 6

SP - 264

EP - 279

JO - Polymers

JF - Polymers

IS - 2

ER -

RGD-Functionalization of Poly(2-oxazoline)-Based Networks for Enhanced Adhesion to Cancer Cells

Abstract

Fields of Expertise

Treatment code (Nähere Zuordnung)

UN SDGs

Access to Document

Fingerprint

Projects

Synthetics methodoloy towards highly-functional poly-oxazolines

Synthetic approaches towards functional polymers

Cite this